ArticleEnvironmental research2024
Per- and polyfluoroalkyl substances and bone mineral content in early adolescence: Modification by diet and physical activity.
Article in Environmental research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Serum concentrations of per- and poly-fluoroalkyl substances (PFAS) in Danish pregnant women-temporal trends during pregnancy, correlations with partners, associations with physical activity, and blood lipid concentrations.Environmental health : a global access science source · 2025Trial
- Relationship between inflammatory indicators and bone mineral density in preschool children.Pediatric research · 2026Article
- Micronutrients as Mitigators of Endocrine Disrupting Chemical Health Effects: A Scoping Review and Framework for Epidemiologic Studies.Current environmental health reports · 2026Article
- Long-term association between phthalate exposure in pregnancy and midlife bone mineral density among women in Mexico City.Environmental health : a global access science source · 2026Article
- Per- and polyfluoroalkyl substances and adolescent bone mineral density: assessing periods of susceptibility.Journal of the Endocrine Society · 2026Article
- Associations of endocrine disrupting chemical biomarkers and their mixture with vitamin D biomarker concentrations in childhood: The HOME Study.Environmental research · 2026Article
- Associations between Per- and Polyfluoroalkyl Substances Exposures and Bone Mineral: A Systematic Review and Best Evidence Synthesis.Environment & health (Washington, D.C.) · 2025Article
- Health Impacts of Per- and Polyfluoroalkyl Substances (PFASs): A Comprehensive Review.Life (Basel, Switzerland) · 2025Review
- Exploring the impact of PFAS exposure and sleep duration on kidney stone formation in the U.S. population.Frontiers in public health · 2025Article
- Mid-Childhood Plasma Concentrations of Per- and Polyfluoroalkyl Substances, Modifiable Lifestyle Factors, and Bone Mineral Density Through Late Adolescence.Environmental science & technology · 2024Article
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Authors and funding
12 authors.
Funding
Abstract
backgroundPer- and polyfluoroalkyl substance (PFAS) exposures may negatively impact bone mineral accrual, but little is known about potential mitigators of this relation. We assessed whether associations of PFAS and their mixture with bone mineral content (BMC) in adolescence were modified by diet and physical activity.
methodsWe included 197 adolescents enrolled in a prospective pregnancy and birth cohort in Cincinnati, Ohio (2003-2006). At age 12 years, we collected serum for PFAS measurements and used dual-energy x-ray absorptiometry to measure BMC. We calculated dietary calcium intake and Health Eating Index (HEI) scores from repeated 24-h dietary recalls, physical activity scores using the Physical Activity Questionnaire for Older Children (PAQ-C), and average moderate to vigorous physical activity (MVPA) based on accelerometry. We estimated covariate-adjusted differences in BMC z-scores per interquartile range (IQR) increase of individual PFAS concentrations using linear regression and per simultaneous IQR increase in all four PFAS using g-computation. We evaluated effect measure modification (EMM) using interaction terms between each modifier and PFAS.
resultsHigher serum perfluorooctanoic acid, perfluorooctanesulfonic acid, and perfluorononanoic acid concentrations and the PFAS mixture were associated with lower BMC z-scores. An IQR increase in all PFAS was associated with a 0.27 (-0.54, 0.01) lower distal radius BMC z-score. Associations with lower BMC were generally stronger among adolescents classified as < median for calcium intake, HEI scores, or MVPA compared to those ≥ median. The difference in distal radius BMC z-score per IQR increase in all PFAS was -0.38 (-0.72, -0.04) for those with <median calcium intake versus -0.03 (-0.48, 0.35) for ≥ median (EMM p-value = 0.16); the corresponding differences by MVPA were -0.42 (-0.76, -0.07) for < median and -0.05 (-0.42, 0.32) for ≥ median (EMM p-value = 0.13).
conclusionHealthy, calcium-rich diets and higher intensity physical activity may mitigate the adverse impact of PFAS on adolescent bone health.
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