Evidence map›Paper›PMID 38579929›Full record

ArticleMolecular & cellular proteomics : MCP2024

The One Hour Human Proteome.

Lia R Serrano, Trenton M Peters-Clarke, Tabiwang N Arrey, Eugen Damoc, Margaret Lea Robinson, Noah M Lancaster, Evgenia Shishkova, Corinne Moss, Anna Pashkova, Pavel Sinitcyn and 10 more

Abstract read
In one paragraph

Article in Molecular & cellular proteomics : MCP, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

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  14. SynchroSep-MS: Parallel LC Separations for Multiplexed Proteomics.Journal of the American Society for Mass Spectrometry · 2025
    Article
  15. Article
  16. Thin-diaPASEF: diaPASEF for maximizing proteome coverage in single-shot proteomics.DNA research : an international journal for rapid publication of reports on genes and genomes · 2025
    Article
  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Lia R SerranoDepartment of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA; Department of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Trenton M Peters-ClarkeDepartment of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA; Department of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Tabiwang N ArreyThermo Fisher Scientific GmbH, Bremen, Germany.
Eugen DamocThermo Fisher Scientific GmbH, Bremen, Germany.
Margaret Lea RobinsonDepartment of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Noah M LancasterDepartment of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA; Department of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Evgenia ShishkovaDepartment of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA; National Center for Quantitative Biology of Complex Systems, Madison, Wisconsin, USA.
Corinne MossDepartment of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Anna PashkovaThermo Fisher Scientific GmbH, Bremen, Germany.
Pavel SinitcynMorgridge Institute for Research, Madison, Wisconsin, USA.
Dain R BrademanMorgridge Institute for Research, Madison, Wisconsin, USA.
Scott T QuarmbyDepartment of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA; National Center for Quantitative Biology of Complex Systems, Madison, Wisconsin, USA.
Amelia C PetersonThermo Fisher Scientific GmbH, Bremen, Germany.
Martin ZellerThermo Fisher Scientific GmbH, Bremen, Germany.
Daniel HermansonThermo Fisher Scientific, San Jose, California, USA.
Hamish StewartThermo Fisher Scientific GmbH, Bremen, Germany.
Christian HockThermo Fisher Scientific GmbH, Bremen, Germany.
Alexander MakarovThermo Fisher Scientific GmbH, Bremen, Germany.
Vlad ZabrouskovThermo Fisher Scientific, San Jose, California, USA.
Joshua J CoonDepartment of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA; Department of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA; National Center for Quantitative Biology of Complex Systems, Madison, Wisconsin, USA; Morgridge Institute for Research, Madison, Wisconsin, USA. Electronic address: jcoon@chem.wisc.edu.

Funding

Institutional Training in the Genomic SciencesT32HG002760 · NHGRI · UNIVERSITY OF WISCONSIN-MADISON · PI Qiongshi Lu · 2003 to 2026
$17.7M
TR&D 2 Metabolic Labels for Ultraplexed Protein Quantification p. 453P41GM108538 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI COON, JOSHUA J · 2016 to 2025
$13.1M
Structure, Function and Regulation of the ProteomeR35GM118110 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI COON, JOSHUA J · 2016 to 2025
$9.1M
RESEARCH TRAINING IN HEMATOLOGYT32HL007899 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Jane Ellen Churpek · 1998 to 2026
$8.2M
Biotechnology Training ProgramT32GM135066 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI SCOTT M. COYLE, BRIAN G FOX · 2020 to 2026
$7.0M
NHGRI NIH HHS T32 HG002760NHLBI NIH HHS T32 HL007899NIGMS NIH HHS P41 GM108538NIGMS NIH HHS R35 GM118110NIGMS NIH HHS T32 GM135066
6 · The paper itself

Abstract

We describe deep analysis of the human proteome in less than 1 h. We achieve this expedited proteome characterization by leveraging state-of-the-art sample preparation, chromatographic separations, and data analysis tools, and by using the new Orbitrap Astral mass spectrometer equipped with a quadrupole mass filter, a high-field Orbitrap mass analyzer, and an asymmetric track lossless (Astral) mass analyzer. The system offers high tandem mass spectrometry acquisition speed of 200 Hz and detects hundreds of peptide sequences per second within data-independent acquisition or data-dependent acquisition modes of operation. The fast-switching capabilities of the new quadrupole complement the sensitivity and fast ion scanning of the Astral analyzer to enable narrow-bin data-independent analysis methods. Over a 30-min active chromatographic method consuming a total analysis time of 56 min, the Q-Orbitrap-Astral hybrid MS collects an average of 4319 MS

Indexed as

ProteomeProteomicsTandem Mass SpectrometryHumansTime FactorsProteomeCRISPRdata independent acquisitionhigh throughputinstrumentationmass spectrometryproteomeproteomicssingle shottechnology development

Identifiers

PMID38579929
PMCPMC11103439

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.