Evidence map›Paper›PMID 38579620›Full record

ArticlePregnancy hypertension2024

Cardiovascular morbidity and mortality following hypertensive disorders of pregnancy.

Lauren H Theilen, Michael W Varner, M Sean Esplin, Benjamin D Horne

Open access · greenAbstract read
In one paragraph

Article in Pregnancy hypertension, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Lauren H TheilenUniversity of Utah Health, Department of Obstetrics and Gynecology, Salt Lake City, UT, United States; Intermountain Healthcare, Women & Newborn Clinical Program, Salt Lake City, UT, United States. Electronic address: lauren.theilen@hsc.utah.edu.
Michael W VarnerUniversity of Utah Health, Department of Obstetrics and Gynecology, Salt Lake City, UT, United States; Intermountain Healthcare, Women & Newborn Clinical Program, Salt Lake City, UT, United States.
M Sean EsplinUniversity of Utah Health, Department of Obstetrics and Gynecology, Salt Lake City, UT, United States; Intermountain Healthcare, Women & Newborn Clinical Program, Salt Lake City, UT, United States.
Benjamin D HorneIntermountain Medical Center Heart Institute, Salt Lake City, UT, United States; Division of Cardiovascular Medicine, Department of Medicine, Stanford University, Stanford, CA, United States.
University of Utah · USIntermountain Healthcare · USIntermountain Medical Center · US

Funding

CTSA UM1 Program at University of UtahUM1TR004409 · NCATS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI RACHEL HESS, Jennifer Juhl Majersik · 2023 to 2026
$21.9M
Optimizing Cardiovascular Preventive Care for Women following Hypertensive Disorders of Pregnancy.K23HL159316 · NHLBI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Lauren Theilen · 2022 to 2026
$885k
NCATS NIH HHS UM1 TR004409NHLBI NIH HHS K23 HL159316
6 · The paper itself

Abstract

objectivesTo determine whether hypertensive disorders of pregnancy (HDP) are associated with maternal coronary artery disease (CAD) and other cardiovascular (CV) diseases within 10-20 years following delivery. STUDY

designRetrospective cohort including all women who delivered ≥ 1 pregnancy ≥ 20 weeks' gestation within a single health system from 1998 to 2008. We excluded those with CV risk factors preceding first delivery or with no follow-up after delivery. The exposure of interest was any HDP, determined by ICD coding.

main outcome measuresThe primary outcome was a composite of ICD codes for CAD, peripheral vascular disease, and CV events (myocardial infarction, stroke, and death). Multivariable Cox proportional hazards estimated the association between exposure and outcomes. A nested cohort of women who underwent cardiac catheterization had a primary outcome of angiographic CAD, and multivariable logistic regression estimated the association between HDP and CAD.

resultsOf 33,959 women included, 2,385 women had HDP. HDP was associated with the composite outcome (adjusted HR 1.50, 95 % CI 1.11, 2.03). There was a significant difference in event-free survival between groups (p = 0.003) with a median follow-up of 17.3 years. 592 women (1.7 %) underwent cardiac catheterization: 20 of 90 women with HDP had CAD (22.2 %) on angiography vs 49 of 502 without HDP (9.8 %, p < 0.001). HDP was associated with angiographic CAD (adjusted OR 2.08, 95 % CI 1.05, 4.11).

conclusionsWomen with HDP had twice the incidence of CAD on angiography compared to parous women without HDP. Obstetric history may inform the decision to perform cardiac catheterization in relatively young women.

Indexed as

Hypertension, Pregnancy-InducedAdultCardiac CatheterizationCardiovascular DiseasesCoronary AngiographyCoronary Artery DiseaseFemaleHumansLogistic ModelsMultivariate AnalysisPregnancyProportional Hazards ModelsRetrospective StudiesRisk FactorsTime FactorsCoronary artery diseaseVascular agingWomen’s health

Identifiers

PMID38579620
PMCPMC11162897
OpenAlexW4393964791

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.