Evidence map›Paper›PMID 38579461›Full record

ReviewBrain and language2024

How does the "default mode" network contribute to semantic cognition?

Leonardo Fernandino, Jeffrey R Binder

Abstract readReview
In one paragraph

Review in Brain and language, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Semantic encoding of trauma memories in the hippocampus among individuals with PTSD.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Trial
  2. Resolving the Abstract-Concrete Paradox in the Angular Gyrus: A Multimethod Investigation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  3. Article
  4. Article
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  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
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  15. Article
  16. A Common Representational Code for Event and Object Concepts in the Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  17. Functions of the posterior cingulate cortex and default network.Current opinion in behavioral sciences · 2025
    Article
  18. Article
  19. Individual differences shape conceptual representation in the brain.bioRxiv : the preprint server for biology · 2025
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Leonardo FernandinoDepartment of Neurology, Medical College of Wisconsin, USA; Department of Biomedical Engineering, Medical College of Wisconsin, USA. Electronic address: lfernandino@mcw.edu.
Jeffrey R BinderDepartment of Neurology, Medical College of Wisconsin, USA; Department of Biophysics, Medical College of Wisconsin, USA.

Funding

Concept Representation in the Human BrainR01DC016622 · NIDCD · MEDICAL COLLEGE OF WISCONSIN · PI BINDER, JEFFREY R · 2018 to 2022
$3.0M
Neural Representation of Lexical ConceptsR01DC020932 · NIDCD · MEDICAL COLLEGE OF WISCONSIN · PI Leonardo F Fernandino · 2024 to 2026
$1.2M
NIDCD NIH HHS R01 DC016622NIDCD NIH HHS R01 DC020932
6 · The paper itself

Abstract

This review examines whether and how the "default mode" network (DMN) contributes to semantic processing. We review evidence implicating the DMN in the processing of individual word meanings and in sentence- and discourse-level semantics. Next, we argue that the areas comprising the DMN contribute to semantic processing by coordinating and integrating the simultaneous activity of local neuronal ensembles across multiple unimodal and multimodal cortical regions, creating a transient, global neuronal ensemble. The resulting ensemble implements an integrated simulation of phenomenological experience - that is, an embodied situation model - constructed from various modalities of experiential memory traces. These situation models, we argue, are necessary not only for semantic processing but also for aspects of cognition that are not traditionally considered semantic. Although many aspects of this proposal remain provisional, we believe it provides new insights into the relationships between semantic and non-semantic cognition and into the functions of the DMN.

Indexed as

CognitionSemanticsBrainDefault Mode NetworkHumans

Identifiers

PMID38579461
PMCPMC11135161

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.