Evidence map›Paper›PMID 38579163›Full record

ReviewACS synthetic biology2024

Bayesian Regression Facilitates Quantitative Modeling of Cell Metabolism.

Teddy Groves, Nicholas Luke Cowie, Lars Keld Nielsen

Abstract readReview
In one paragraph

Review in ACS synthetic biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Teddy GrovesThe Novo Nordisk Foundation Center for Biosustainability, DTU, Kongens Lyngby 2800, Denmark.ORCID 0000-0002-7109-3270
Nicholas Luke CowieThe Novo Nordisk Foundation Center for Biosustainability, DTU, Kongens Lyngby 2800, Denmark.
Lars Keld NielsenThe Novo Nordisk Foundation Center for Biosustainability, DTU, Kongens Lyngby 2800, Denmark.ORCID 0000-0001-8191-3511

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This paper presents Maud, a command-line application that implements Bayesian statistical inference for kinetic models of biochemical metabolic reaction networks. Maud takes into account quantitative information from omics experiments and background knowledge as well as structural information about kinetic mechanisms, regulatory interactions, and enzyme knockouts. Our paper reviews the existing options in this area, presents a case study illustrating how Maud can be used to analyze a metabolic network, and explains the biological, statistical, and computational design decisions underpinning Maud.

Indexed as

Gene Regulatory NetworksBayes TheoremKineticsBayesian inferencekinetic models of cell metabolismmultiomics integrationordinary differential equationsregulatory anlaysis

Identifiers

PMID38579163
PMCPMC11036490

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.