Evidence map›Paper›PMID 38578905›Full record

ArticleJournal of neonatal-perinatal medicine2024

Heart rate and oxygen saturation patterns in very low birth weight infants with early onset sepsis and histologic chorioamnionitis.

Charlene R Bultmann, Jiaxang Qiu, Briana Belmonte, Karen D Fairchild, Brynne A Sullivan

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Article in Journal of neonatal-perinatal medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Charlene R BultmannDepartment of Pediatrics, University of Virginia, Charlottesville, VA, USA.
Jiaxang QiuDepartment of Medicine, University of Virginia, Charlottesville, VA, USA.
Briana BelmonteDepartment of Pediatrics, University of Texas Southwestern, Dallas, TX, USA.
Karen D FairchildDepartment of Pediatrics, University of Virginia, Charlottesville, VA, USA.
Brynne A SullivanDepartment of Pediatrics, University of Virginia, Charlottesville, VA, USA.

Funding

Predictive Informatics Monitoring in the Neonatal Intensive Care UnitR01HD072071 · NICHD · UNIVERSITY OF VIRGINIA · PI KAREN D FAIRCHILD, Brynne Archer Sullivan · 2014 to 2026
$7.6M
Integrated physiomarker, biomarker and clinical predictive analytics for early warning of sepsis and necrotizing enterocolitis in very low birth weight infants.K23HD097254 · NICHD · UNIVERSITY OF VIRGINIA · PI SULLIVAN, BRYNNE ARCHER · 2019 to 2023
$897k
NICHD NIH HHS K23 HD097254NICHD NIH HHS R01 HD072071
6 · The paper itself

Abstract

backgroundChorioamnionitis and early onset sepsis (EOS) in very low birth weight (VLBW,< 1500 g) infants may cause a systemic inflammatory response reflected in patterns of heart rate (HR) and oxygenation measured by pulse oximetry (SpO2). Identification of these patterns might inform decisions about duration of antibiotic therapy after birth.

objectiveCompare early HR and SpO2 patterns in VLBW infants with or without early onset sepsis (EOS) or histologic chorioamnionitis (HC). STUDY

designRetrospective study of placental pathology and HR and SpO2 in the first 72 h from birth in relation to EOS status for inborn VLBW NICU patients 2012-2019.

resultAmong 362 VLBW infants with HR and SpO2 data available, clinical, or culture-positive EOS occurred in 91/362 (25%) and HC in 81/355 (22%). In univariate analysis, EOS was associated with higher mean HR, lower mean SpO2, and less negative skewness of HR in the first 3 days after birth. HC was associated with higher standard deviation and skewness of HR but no difference in SpO2. In multivariable modeling, significant risk factors for EOS were mean HR, gestational age, HC, mean SpO2, and skewness of SpO2.

conclusionHR and SpO2 patterns differ shortly after birth in VLBW infants exposed to HC or with EOS, likely reflecting a systemic inflammatory response.

Indexed as

ChorioamnionitisHeart RateInfant, Very Low Birth WeightOximetryOxygen SaturationFemaleGestational AgeHumansInfant, NewbornIntensive Care Units, NeonatalMaleNeonatal SepsisPregnancyRetrospective StudiesRisk FactorsSepsisChorioamnionitisearly onset sepsisheart rateoxygenationpremature infantsvery low birth weightvital signs

Identifiers

PMID38578905
PMCPMC11450634

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.