Evidence map›Paper›PMID 38578669›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2024

Parkinson's disease cerebrovascular reactivity pattern: A feasibility study.

Harm Jan van der Horn, Andrei A Vakhtin, Kayla Julio, Stephanie Nitschke, Nicholas Shaff, Andrew B Dodd, Erik Erhardt, John P Phillips, Sarah Pirio Richardson, Amanda Deligtisch and 5 more

Open access · greenAbstract read
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Cerebrovascular reactivity delay measured by blood oxygen level dependent magnetic resonance imaging and gas challenges: A systematic review.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. The dependence of COImaging neuroscience (Cambridge, Mass.) · 2025
    Article
  8. Abnormal Cerebrovascular Activity, Perfusion, and Glymphatic Clearance in Lewy Body Diseases.Movement disorders : official journal of the Movement Disorder Society · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Harm Jan van der HornDepartment of Translational Neuroscience, The Mind Research Network, Albuquerque, NM, USA.
Andrei A VakhtinDepartment of Translational Neuroscience, The Mind Research Network, Albuquerque, NM, USA.
Kayla JulioDepartment of Translational Neuroscience, The Mind Research Network, Albuquerque, NM, USA.
Stephanie NitschkeDepartment of Translational Neuroscience, The Mind Research Network, Albuquerque, NM, USA.
Nicholas ShaffDepartment of Translational Neuroscience, The Mind Research Network, Albuquerque, NM, USA.
Andrew B DoddDepartment of Translational Neuroscience, The Mind Research Network, Albuquerque, NM, USA.
Erik ErhardtDepartment of Mathematics and Statistics, University of New Mexico, Albuquerque, NM, USA.
John P PhillipsDepartment of Translational Neuroscience, The Mind Research Network, Albuquerque, NM, USA.
Sarah Pirio RichardsonNene and Jamie Koch Comprehensive Movement Disorder Center, Department of Neurology, University of New Mexico, Albuquerque, NM, USA.
Amanda DeligtischNene and Jamie Koch Comprehensive Movement Disorder Center, Department of Neurology, University of New Mexico, Albuquerque, NM, USA.
Melanie StewartNene and Jamie Koch Comprehensive Movement Disorder Center, Department of Neurology, University of New Mexico, Albuquerque, NM, USA.
Gerson Suarez CedenoNene and Jamie Koch Comprehensive Movement Disorder Center, Department of Neurology, University of New Mexico, Albuquerque, NM, USA.
Sanne K MelesDepartment of Neurology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Andrew R MayerDepartment of Translational Neuroscience, The Mind Research Network, Albuquerque, NM, USA.
Sephira G RymanDepartment of Translational Neuroscience, The Mind Research Network, Albuquerque, NM, USA.
Mind Research Network · USUniversity of New Mexico · USNew Mexico VA Health Care System · USUniversity of Groningen · NL

Funding

Research Education ComponentP30AG086404 · NIA · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI ELAINE L BEARER · 2024 to 2026
$17.7M
The Impact of Diffuse Mild Brain Injury on Clinical Outcomes in ChildrenR01NS098494 · NINDS · THE MIND RESEARCH NETWORK · PI Andrew Robert Mayer · 2016 to 2026
$7.6M
Pilot Project Program (PPP)P30GM122734 · NIGMS · THE MIND RESEARCH NETWORK · PI MAYER, ANDREW ROBERT · 2018 to 2022
$7.0M
Validation of Biomarkers of Small Vessel Injury in VCIDUF1NS100598 · NINDS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI ROSENBERG, GARY ALLEN · 2021 to 2023
$6.3M
MRI and CSF Biomarkers of White Matter Injury in VCIDUH3NS100598 · NINDS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI ROSENBERG, GARY ALLEN · 2018 to 2020
$3.3M
Microbiome-gut-brain dysfunction in prodromal and symptomatic Lewy body diseasesR01NS133569 · NINDS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Sephira Ryman · 2023 to 2026
$3.2M
Scientific CoreP20AG068077 · NIA · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI ROSENBERG, GARY ALLEN · 2020 to 2022
$3.1M
MRI and CSF Biomarkers of White Matter Injury in VCIDUH2NS100598 · NINDS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI ROSENBERG, GARY ALLEN · 2016 to 2017
$2.1M
Siemens MAGNETOM Prisma/Prisma fit upgradeS10OD025313 · OD · THE MIND RESEARCH NETWORK · PI MAYER, ANDREW ROBERT · 2018 to 2018
$1.5M
Electroconvulsive therapy amplitude titration for improved clinical outcomes in late-life depressionR61MH125126 · NIMH · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI ABBOTT, CHRISTOPHER C · 2021 to 2022
$1.4M
Cerebrovascular contributions to cognitive impairment in Lewy body dementiasR03AG075408 · NIA · LOVELACE BIOMEDICAL RESEARCH INSTITUTE · PI RYMAN, SEPHIRA · 2022 to 2023
$362k
NIA NIH HHS P20 AG068077NIA NIH HHS P30 AG086404NIA NIH HHS R03 AG075408NIGMS NIH HHS P30 GM122734NIH HHS S10 OD025313NIMH NIH HHS R61 MH125126NINDS NIH HHS R01 NS098494NINDS NIH HHS R01 NS133569NINDS NIH HHS UF1 NS100598NINDS NIH HHS UH2 NS100598NINDS NIH HHS UH3 NS100598
6 · The paper itself

Abstract

A mounting body of research points to cerebrovascular dysfunction as a fundamental element in the pathophysiology of Parkinson's disease (PD). In the current feasibility study, blood-oxygen-level-dependent (BOLD) MRI was used to measure cerebrovascular reactivity (CVR) in response to hypercapnia in 26 PD patients and 16 healthy controls (HC), and aimed to find a multivariate pattern specific to PD. Whole-brain maps of CVR amplitude (i.e., magnitude of response to CO

Indexed as

Cerebrovascular CirculationFeasibility StudiesMagnetic Resonance ImagingParkinson DiseaseAgedBrainFemaleHumansHypercapniaMaleMiddle AgedCarbon dioxidecovarianceneurodegenerationneuromelaninneurovascular coupling

Identifiers

PMID38578669
PMCPMC11494834
OpenAlexW4393996608

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.