Evidence map›Paper›PMID 38578631›Full record

ArticleJournal of molecular cell biology2024

Indomethacin restrains cytoplasmic nucleic acid-stimulated immune responses by inhibiting the nuclear translocation of IRF3.

Miao Wang, Xiao-Wei Li, Sen-Chao Yuan, Jie Pan, Zeng-Lin Guo, Li-Ming Sun, Shao-Zhen Jiang, Ming Zhao, Wen Xue, Hong Cai and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular cell biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 2 institutions in 1 country.

Miao WangNanhu Laboratory, National Center of Biomedical Analysis, Beijing 100850, China.
Xiao-Wei LiNanhu Laboratory, National Center of Biomedical Analysis, Beijing 100850, China.
Sen-Chao YuanNanhu Laboratory, National Center of Biomedical Analysis, Beijing 100850, China.
Jie PanNanhu Laboratory, National Center of Biomedical Analysis, Beijing 100850, China.
Zeng-Lin GuoNanhu Laboratory, National Center of Biomedical Analysis, Beijing 100850, China.
Li-Ming SunNanhu Laboratory, National Center of Biomedical Analysis, Beijing 100850, China.
Shao-Zhen JiangNanhu Laboratory, National Center of Biomedical Analysis, Beijing 100850, China.
Ming ZhaoNanhu Laboratory, National Center of Biomedical Analysis, Beijing 100850, China.
Wen XueNanhu Laboratory, National Center of Biomedical Analysis, Beijing 100850, China.
Hong CaiNanhu Laboratory, National Center of Biomedical Analysis, Beijing 100850, China.
Lin GuNanhu Laboratory, National Center of Biomedical Analysis, Beijing 100850, China.
Dan LuoNanhu Laboratory, National Center of Biomedical Analysis, Beijing 100850, China.
Ling ChenNanhu Laboratory, National Center of Biomedical Analysis, Beijing 100850, China.
Xue-Qing ZhouNanhu Laboratory, National Center of Biomedical Analysis, Beijing 100850, China.
Qiu-Ying HanNanhu Laboratory, National Center of Biomedical Analysis, Beijing 100850, China.
Jin LiNanhu Laboratory, National Center of Biomedical Analysis, Beijing 100850, China.
Tao ZhouNanhu Laboratory, National Center of Biomedical Analysis, Beijing 100850, China.
Tian XiaNanhu Laboratory, National Center of Biomedical Analysis, Beijing 100850, China.ORCID 0000-0002-1527-2194
Tao LiNanhu Laboratory, National Center of Biomedical Analysis, Beijing 100850, China.
National Center of Biomedical Analysis · CNShanghai Medical College of Fudan University · CN

Funding

National Key Research and Development Program of China 2020YFA0707703National Natural Science Foundation of China 82001690
6 · The paper itself

Abstract

The recognition of cytosolic nucleic acid triggers the DNA/RNA sensor-IRF3 axis-mediated production of type I interferons (IFNs), which are essential for antiviral immune responses. However, the inappropriate activation of these signaling pathways is implicated in autoimmune conditions. Here, we report that indomethacin, a widely used nonsteroidal anti-inflammatory drug, inhibits nucleic acid-triggered IFN production. We found that both DNA- and RNA-stimulated IFN expression can be effectively blocked by indomethacin. Interestingly, indomethacin also prohibits the nuclear translocation of IRF3 following cytosolic nucleic acid recognition. Importantly, in cell lines and a mouse model of Aicardi-Goutières syndrome, indomethacin administration blunts self-DNA-induced autoimmune responses. Thus, our study reveals a previously unknown function of indomethacin and provides a potential treatment for cytosolic nucleic acid-stimulated autoimmunity.

Indexed as

IndomethacinInterferon Regulatory Factor-3Active Transport, Cell NucleusAnimalsAutoimmune Diseases of the Nervous SystemAutoimmunityCell NucleusCytoplasmCytosolDisease Models, AnimalHEK293 CellsHumansInterferon Type IMiceMice, Inbred C57BLNervous System MalformationsIndomethacinInterferon Regulatory Factor-3Interferon Type IIRF3 protein, humanIrf3 protein, mouseNucleic Acidsautoimmune diseasesindomethacinIRF3 nuclear translocation

Identifiers

PMID38578631
PMCPMC11472148
OpenAlexW4394019123

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.