Evidence map›Paper›PMID 38578529›Full record

SynthesisNeurosurgical review2024

The impact of perioperative nonsteroidal anti-inflammatory drugs on the postoperative outcomes of spinal surgery: a meta-analysis of 23 randomized controlled trials.

Mingjiang Luo, Gaigai Yang, Huijie Dai, Fuwen Shi, Zhifeng Tang, Jijun Tan, Yang Kang, Jing Jiang, Jie Xie, Zhiyuan Yi and 5 more

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Neurosurgical review, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Mingjiang LuoDepartment of spinal Surgery, Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang City, Hunan Province, 421000, China.
Gaigai YangHengyang Medical School, University of South China, Hengyang City, Hunan Province, China.
Huijie DaiHengyang Medical School, University of South China, Hengyang City, Hunan Province, China.
Fuwen ShiHengyang Medical School, University of South China, Hengyang City, Hunan Province, China.
Zhifeng TangHengyang Medical School, University of South China, Hengyang City, Hunan Province, China.
Jijun TanHengyang Medical School, University of South China, Hengyang City, Hunan Province, China.
Yang KangHengyang Medical School, University of South China, Hengyang City, Hunan Province, China.
Jing JiangHengyang Medical School, University of South China, Hengyang City, Hunan Province, China.
Jie XieHengyang Medical School, University of South China, Hengyang City, Hunan Province, China.
Zhiyuan YiHengyang Medical School, University of South China, Hengyang City, Hunan Province, China.
Beijun ZhouHengyang Medical School, University of South China, Hengyang City, Hunan Province, China.
Zuoxuan ChenHengyang Medical School, University of South China, Hengyang City, Hunan Province, China.
Hongxu WangHengyang Medical School, University of South China, Hengyang City, Hunan Province, China.
Deyao KongHengyang Medical School, University of South China, Hengyang City, Hunan Province, China.
Zhihong XiaoDepartment of spinal Surgery, Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang City, Hunan Province, 421000, China. 482923528@qq.com.
University of South China · CN

Funding

Health and Family Planning Commission Program of Hunan Province 202204074707Health and Family Planning Commission Program of Wuhan City WX18C29
6 · The paper itself

Abstract

In recent years, nonsteroidal anti-inflammatory drug (NSAIDs), which are considered to affect the prognosis of spinal surgery, have been widely used in perioperative analgesia in spinal surgery, but the relationship between these two factors remains unclear. The purpose of this study was to explore the effect of perioperative use of NSAIDs on the prognosis of patients treated with spinal surgery. We systematically searched PubMed, Embase, and Cochrane Library for relevant articles published on or before July 14, 2023. We used a random-effect model for the meta-analysis to calculate the standardized mean difference (SMD) with a 95% confidence interval (CI). Sensitivity analyses were conducted to analyze stability. A total of 23 randomized clinical trials including 1457 participants met the inclusion criteria. Meta-analysis showed that NSAIDs were significantly associated with postoperative morphine use (mg) (SMD = -0.90, 95% CI -1.12 to -0.68) and postoperative pain (SMD = -0.71, 95% CI -0.85 to -0.58). These results were further confirmed by the trim-and-fill procedure and leave-one-out sensitivity analyses. The current study shows that perioperative use of NSAIDs appears to be an important factor in reducing postoperative pain and morphine use in patients undergoing spinal surgery. However, well-designed, high-quality randomized controlled trials (RCTs) are still required.

Indexed as

Anti-Inflammatory Agents, Non-SteroidalPostoperative PainSpineHumansMorphine DerivativesRandomized Controlled Trials as TopicAnti-Inflammatory Agents, Non-SteroidalMorphine DerivativesMeta-analysis and randomized controlled trialsNonsteroidal anti-inflammatory drugsSpinal surgery

Identifiers

PMID38578529
OpenAlexW4393991920

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.