Evidence map›Paper›PMID 38578389›Full record

ArticleJournal of clinical immunology2024

COVID-19 Vaccination in Patients with Inborn Errors of Immunity Reduces Hospitalization and Critical Care Needs Related to COVID-19: a USIDNET Report.

John McDonnell, Kimberley Cousins, M Elizabeth M Younger, Adam Lane, Hassan Abolhassani, Roshini S Abraham, Salem Al-Tamemi, Juan Carlos Aldave-Becerra, Eman Hesham Al-Faris, Alberto Alfaro-Murillo and 148 more

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Article in Journal of clinical immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

158 authors at 20 institutions in 26 countries.

John McDonnellPediatric Allergy and Immunology, Cleveland Clinic Children's Hospital, 9500 Euclid Ave/R3, Cleveland, OH, 44195, USA. mcdonnj@ccf.org.ORCID 0000-0002-7438-5471
Kimberley CousinsClinical Immunology, Departments of Medicine and Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
M Elizabeth M YoungerJohns Hopkins University School of Medicine, Baltimore, MD, USA.
Adam LaneDivision of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Hassan AbolhassaniDepartment of Biosciences and Nutrition, Karolinska Institute, Stockholm, Sweden.
Roshini S AbrahamDepartment of Pathology and Laboratory Medicine, Nationwide Children's Hospital, Columbus, USA.
Salem Al-TamemiDepartment of Child Health, Sultan Qaboos University Hospital, Muscat, Oman.
Juan Carlos Aldave-BecerraAllergy and Clinical Immunology, Hospital Nacional Edgardo Rebagliati Martins, Lima, Peru.
Eman Hesham Al-FarisDepartment of Internal Medicine, King Fahad Specialist Hospital, Dammam, Saudi Arabia.
Alberto Alfaro-MurilloDepartment of Internal Medicine and Clinical Immunology, Hospital San Juan de Dios, San José, Costa Rica.
Suzan A AlKhaterDepartment of Pediatrics, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
Nouf AlsaatiDivision of Allergy and Immunology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Alexa Michelle Altman DossDivision of Pediatric Allergy, Immunology, and Pulmonary Medicine, St. Louis Children's Hospital, St. Louis, MO, USA.
Melissa AndersonDivision of Allergy Immunology Pulmonary and Sleep Medicine, Department of Pediatrics, Children's Mercy Kansas City, University of Missouri-Kansas City, Kansas City, MO, USA.
Ernestina AngarolaImmunology and Histocompatibility Unit, Hospital C. G. Durand, Buenos Aires, Argentina.
Barbara AriueDepartment of Pediatrics, Division of Allergy and Immunology, Loma Linda Children's Hospital, Loma Linda, CA, USA.
Danielle E ArnoldImmune Deficiency-Cellular Therapy Program, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Amal H Assa'adDivision of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, USA.
Caner AytekinDepartment of Pediatric Immunology, Dr. Sami Ulus Maternity and Children's Health and Diseases Training and Research Hospital, Ankara, Turkey.
Meaghan BankDepartment of Internal Medicine, Louisiana State University Health Sciences Center, New Orleans, USA.
Jenna R E BergersonLaboratory of Clinical Immunology and Microbiology, NIAID, NIH, Rockville, MD, USA.
Jack BleesingDivision of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
John BoesingCincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Carolina BousoImmunology Department, Hospital Nacional de Pediatría Prof. Dr. Juan P. Garrahan, Buenos Aires, Argentina.
Nicholas BrodszkiDepartment of Pediatric Immunology, Children's Hospital, Lund University Hospital, Lund, Sweden.
Diana CabanillasImmunology Unit-Hospital Sor María Ludovica, La Plata, Argentina.
Carol CadyCommunity Medical Center, Missoula, MT, USA.
Meghan A CallahanLake Erie College of Osteopathic Medicine, Elmira, USA.
Roberta CaorsiCenter for Autoinflammatory Diseases and Immunodeficiencies, IRCCS Istituto Giannina Gaslini, 16147, Genoa, Italy.
Javier CarboneImmunology Department, Hospital General Universitario Gregorio Maranon, Madrid, Spain.
Maria CarrabbaDepartment of Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Riccardo CastagnoliPediatric Unit, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy.
Jason R CatanzaroSection of Pulmonology, Allergy, Immunology and Sleep Medicine, Department of Pediatrics, Yale University School of Medicine, New Haven, CT, USA.
Samantha ChanDepartment of Clinical Immunology & Allergy, Royal Melbourne Hospital, Melbourne, VIC, Australia.
Sharat ChandraDivision of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Hugo ChapdelaineClinical Immunology, Montreal Clinical Research Institute, Université de Montréal, Montreal, Canada.
Zahra ChavoshzadehImmunology and Allergy Department, Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Hey Jin ChongDivision of Allergy and Immunology, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Lori ConnorsDepartment of Medicine, Dalhousie University, Halifax, NS, Canada.
Filippo ConsonniCentre of Excellence, Division of Pediatric Oncology and Hematology, Meyer Children's Hospital IRCCS, Florence, Italy.
Oscar Correa-JimenezPediatric Pulmonology and Immunology Research Group, Universidad Nacional de Colombia, Bogotá, Colombia.
Charlotte Cunningham-RundlesClinical Immunology, Departments of Medicine and Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Katherine D'Astous-GauthierDepartment of Pediatric Clinical Immunology and Allergy, University of Sherbrooke, Sherbrooke, QC, Canada.
Ottavia Maria DelmonteLaboratory of Clinical Immunology and Microbiology, NIAID, NIH, Rockville, MD, USA.
Yesim Yilmaz DemirdagDivision of Basic and Clinical Immunology, Department of Medicine, University of California, Irvine, CA, USA.
Deepti R DeshpandeDepartment of Pediatrics, Columbia University Medical Center, New York, NY, USA.
Natalie M Diaz-CabreraDivision of Allergy and Immunology, Department of Internal Medicine, University of South Florida Morsani College of Medicine, Tampa, FL, USA.
Victoria R DimitriadesDivision of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of California Davis Health, Sacramento, CA, USA.
Rasha El-OwaidyPediatric Allergy, Immunology and Rheumatology Unit, Children's Hospital, Ain Shams University, Cairo, Egypt.
Gehad ElGhazaliAbu Dhabi and College of Medicine and Health Sciences, Sheikh Khalifa Medical City, Union71 - Purehealth, United Arab Emirates University, Al Ain, United Arab Emirates.
Suleiman Al-HammadiCollege of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates.
Giovanna FabioDepartment of Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Astrid Schellnast FaureHospital Sor María Ludovica, La Plata, Argentina.
Jin FengClinical Immunology, Department of Medicine at Icahn School of Medicine at Mount Sinai, New York, NY, USA.
James M FernandezDepartment of Allergy & Clinical Immunology, Cleveland Clinic Foundation, Cleveland, OH, USA.
Lauren FillUniversity Hospitals, Cleveland Medical Centers, Cleveland, OH, USA.
Guacira R FrancoDivision of Clinical Immunology and Allergy, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
Robert W FrenckDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Ramsay L FuleihanDivision of Pediatric Allergy, Immunology and Rheumatology, Columbia University Medical Center, New York, NY, USA.
Giuliana GiardinoPediatric Section, Department of Translational Medical Science, Federico II University, Naples, Italy.
Jessica Galant-SwaffordDivision of Allergy & Clinical Immunology, National Jewish Health, Denver, CO, USA.
Eleonora GambineriCentre of Excellence, Division of Pediatric Oncology and Hematology, Meyer Children's Hospital IRCCS, Florence, Italy.
Elizabeth K GarabedianNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Ashley V GeerlinksPediatric Hematology and Oncology, Children's Hospital, Western University, London, ON, Canada.
Ekaterini GoudourisDivision of Allergy and Clinical Immunology - IPPMG, Universidade Federal Do Rio de Janeiro, Rio de Janeiro, Brazil.
Octavio GreccoDivision of Clinical Immunology and Allergy, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
Qiang Pan-HammarströmDepartment of Biosciences and Nutrition, Karolinska Institute, Stockholm, Sweden.
Hedieh Haji Khodaverdi KhaniImmunology and Allergy Department, Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Lennart HammarströmDepartment of Biosciences and Nutrition, Karolinska Institute, Stockholm, Sweden.
Nicholas L HartogHelen DeVos Children's Hospital Division of Allergy and Immunology, Michigan State University College of Human Medicine, East Lansing, MI, USA.
Jennifer HeimallDivision of Allergy and Immunology, Department of Pediatrics, Perelman School of Medicine at University of Pennsylvania, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
Gabriela Hernandez-MolinaImmunology and Rheumatology Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
Caroline C HornerDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA.
Robert W HostofferUniversity Hospitals, Cleveland Medical Centers, Cleveland, OH, USA.
Nataliya HristovaDepartment of Clinical Immunology and Stem Cell Bank, University Hospital Álexandrovska, Sofia, Bulgaria.
Kuang-Chih HsiaoStarship Child Health, Auckland, New Zealand.
Gabriela Ivankovich-EscotoDepartment of Pediatrics, Caja Costarricense de Seguro Social, Hospital Nacional de Niños, San José, Costa Rica.
Faris JaberClinical Immunology, Department of Medicine at Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Maaz JalilAdvanced ENT & Allergy, Medford, NJ, USA.
Mahnaz JameePediatric Nephrology Research Center, Research Institute for Children's Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Tiffany JeanDivision of Basic and Clinical Immunology, Department of Medicine, University of California, Irvine, CA, USA.
Stephanie JeongClinical Immunology, Department of Medicine at Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Devi JhaveriAllergy Immunology Associates Inc., Allergy Immunology Fellowship Associate Program Director University Hospitals of Cleveland Medical Center, Cleveland, USA.
Michael B JordanDivision of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Avni Y JoshiMayo Clinic Children's Center, Pediatric and Adult Allergy and Immunology, Mayo Clinic, Rochester, MN, USA.
Amanpreet KalkatUniversity Hospitals, Cleveland Medical Centers, Cleveland, OH, USA.
Henry J KanarekKanarek Allergy Asthma Immunology, Overland Park, KS, USA.
Erinn S KellnerDivision of Allergy and Immunology, Cincinnati Children's Hospital Medical Center and University of Cincinnati, Cincinnati, OH, USA.
Amer KhojahDepartment of Pediatrics, College of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia.
Ruby KhouryDivision of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Cristina M KokronDivision of Clinical Immunology and Allergy, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
Ashish KumarDivision of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Kelsey LecerfDivision of Allergy and Immunology, Department of Pediatrics, Nationwide Children's Hospital and The Ohio State University College of Medicine, Columbus, OH, USA.
Heather K LehmanDepartment of Pediatrics, University of Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY, USA.
Jennifer W LeidingDivision of Allergy and Immunology, Department of Pediatrics, Johns Hopkins University, Baltimore, MD, USA.
Harry LesmanaMolecular Medicine, Cleveland Clinic Lerner College of Medicine, Cleveland, OH, USA.
Xin Rong LimDepartment of Rheumatology, Allergy and Immunology, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore, 308433, Singapore.
Joao Pedro LopesUH Rainbow Babies and Children's Hospital, Case Western Reserve University, Cleveland, OH, USA.
Ana Laura LópezUnidad de Inmunología E Histocompatibilidad, Hospital Dr. Carlos G. Durand, Buenos Aires, Argentina.
Lucia TarquiniSection of Pathological Anatomy and Histopathology, Polytechnic University of the Marche Region, 60020, Ancona, Italy.
Ingrid S LundgrenPediatric Infectious Diseases, St. Luke's Children's Hospital, Boise, ID, USA.
Julieann MagnussonUSIDNET, Towson, MD, USA.
Ana Karolina B B MarinhoDivision of Clinical Immunology and Allergy, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
Gian Luigi MarsegliaPediatric Unit, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy.
Giulia M MartoneDepartment of Pediatrics, University of Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY, USA.
Annamaria G MechtlerUniversity of Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY, USA.
Leonardo MendoncaDivision of Clinical Immunology and Allergy, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
Joshua D MilnerDepartment of Pediatrics, Columbia University Irving Medical Center, New York, NY, USA.
Peter J MustilloDivision of Allergy and Immunology, Department of Pediatrics, Nationwide Children's Hospital and The Ohio State University Wexner College of Medicine, Columbus, OH, USA.
Asal Gharib NaderiAllergy & Immunology, Keck School of Medicine of USC, Los Angeles, CA, USA.
Samuele NaviglioPediatric Hematology-Oncology, Institute for Maternal and Child Health IRCCS "Burlo Garofolo,", Trieste, Italy.
Jeremy NellDepartment of Infection and Tropical Medicine, Newcastle Upon Tyne Hospitals National Health Service (NHS) Foundation Trust and Translational and Clinical Research Institute, Newcastle University, Newcastle Upon Tyne, UK.
Hana B NieburDepartment of Pediatrics, University of Nebraska Medical Center, Children's Hospital and Medical Center, Omaha, NE, USA.
Luigi NotarangeloLaboratory of Clinical Immunology and Microbiology, NIAID, NIH, Rockville, MD, USA.
Matias OleastroImmunology Department, Hospital Nacional de Pediatría Prof. Dr. Juan P. Garrahan, Buenos Aires, Argentina.
María Claudia Ortega-LópezDivision of Pediatrics, Allergy and Clinical Immunology, Hospital Infantil Universitario de San José, Bogotá, Colombia.
Neil R PatelDepartment of Pediatrics, Children's National Hospital, Washington, D.C., USA.
Gordana PetrovicDepartment of Clinical Immunology and Allergology, Institute of Mother and Child Health, Belgrade, Serbia.
Claudio PignataPediatrics, Department of Translational Medical Sciences, Federico II University, Naples, Italy.
Oscar PorrasPediatric Immunology and Rheumatology Department, Hospital Nacional de Niños "Dr. Carlos Sáenz Herrera,", San José, Costa Rica.
Benjamin T PrinceDivision of Allergy and Immunology, Department of Pediatrics, Nationwide Children's Hospital and The Ohio State University Wexner College of Medicine, Columbus, OH, USA.
Jennifer M PuckDivision of Allergy and Immunology and Blood and Marrow Transplantation, Department of Pediatrics, University of California San Francisco School of Medicine and UCSF Benioff Children's Hospital, San Francisco, CA, USA.
Nashmia QamarDivision of Allergy and Immunology, Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Marco RabusinPediatric Hematology-Oncology, Institute for Maternal and Child Health IRCCS "Burlo Garofolo,", Trieste, Italy.
Nikita RajeDivision of Allergy Immunology Pulmonary and Sleep Medicine, Department of Pediatrics, Children's Mercy Kansas City, University of Missouri-Kansas City, Kansas City, MO, USA.
Lorena RegairazChief of Immunology Unit, Children's Hospital "Sor María Ludovica, Buenos Aires, Argentina.
Kimberly A RismaDivision of Allergy Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Elizabeth H RistagnoDivision of Pediatric Infectious Diseases, Mayo Clinic, Rochester, MN, USA.
John RoutesDepartment of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA.
Persio Roxo-JuniorDivision of Immunology and Allergy, Department of Pediatrics, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.
Negin SalemiImmunodeficiency Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Christopher ScalchunesImmune Deficiency Foundation, 7550 Teague Road, Hanover, MD, 21076, USA.
Susan J SchuvalDivision of Allergy and Immunology, Stony Brook Children's Hospital, Stony Brook, NY, USA.
Suranjith L SeneviratneDepartment of Clinical Immunology, Nawaloka Hospitals, Colombo, Sri Lanka.
Ashwin ShankarUniversity Hospitals, Cleveland Medical Centers, Cleveland, OH, USA.
Roya SherkatImmunodeficiency Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Junghee Jenny ShinSection of Rheumatology, Allergy and Immunology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
Abeer SiddiqiHouston ENT and Allergy, Houston, TX, USA.
Sara SignaCenter for Autoinflammatory Diseases and Immunodeficiencies, IRCCS Istituto Giannina Gaslini, 16147, Genoa, Italy.
Ali SobhDepartment of Pediatrics, Faculty of Medicine, Mansoura University Children's Hospital, Mansoura University, Mansoura, Egypt.
Fabiana Mascarenhas Souza LimaDivision of Clinical Immunology and Allergy, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
Kristen K StenehjemDepartment of Pediatrics, Children's National Hospital, Washington, D.C., USA.
Jonathan S TamChildren's Hospital Los Angeles, Los Angeles, CA, USA.
Monica TangDivision of Pulmonary, Critical Care, Allergy, and Sleep Medicine, University of California San Francisco, San Francisco, USA.
Myrthes Toledo BarrosDivision of Clinical Immunology and Allergy, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
James VerbskyDepartment of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA.
Eleni VergadiDepartment of Paediatrics, Medical School, University of Crete, Rethymno, Greece.
Dayne H VoelkerDivision of Allergy and Immunology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Stefano VolpiCenter for Autoinflammatory Diseases and Immunodeficiencies, IRCCS Istituto Giannina Gaslini, 16147, Genoa, Italy.
Luke A WallSection of Allergy Immunology, Department of Pediatrics, Louisiana State University Health and Children's Hospital New Orleans, New Orleans, LA, USA.
Christine WangSection of Rheumatology, Department of Pediatrics, Children's Hospital of Colorado, University of Colorado School of Medicine, Aurora, CO, USA.
Kelli W WilliamsDivision of Pediatric Pulmonology, Allergy and Immunology, Department of Pediatrics, Medical University of South Carolina, Charleston, SC, USA.
Eveline Y WuDivision of Pediatric Allergy and Immunology, Department of Pediatrics, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Shan Shan WuUniversity Hospitals Cleveland Medical Center, Cleveland, OH, USA.
Jessie J ZhouDepartment of Clinical Immunology & Allergy, The Royal Melbourne Hospital, Melbourne, Australia.
Alexandria CookDepartment of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA.
Kathleen E SullivanDivision of Allergy and Immunology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Rebecca MarshDivision of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Cincinnati Children's Hospital Medical Center · USHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · BRUniversity Hospitals of Cleveland · USIcahn School of Medicine at Mount Sinai · USNationwide Children's Hospital · USChildren's Hospital of Philadelphia · USColumbia University Irving Medical Center · USHospital de Niños Superiora Sor María Ludovica · ARIstituto Giannina Gaslini · ITJacobs Institute · USKarolinska Institutet · SEMedical College of Wisconsin · USNational Institute of Allergy and Infectious Diseases · USShahid Beheshti University of Medical Sciences · IRChildren's National · USCleveland Clinic · USEl Hospital General de Agudos Carlos G. Durand · ARFederico II University Hospital · ITFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITGarrahan Hospital · AR

Funding

USIDNET: A resource for clinical immunologistsR24AI171055 · NIAID · CHILDREN'S HOSP OF PHILADELPHIA · PI KATHLEEN E SULLIVAN · 2022 to 2026
$7.0M
Characterization of host immune responses to SARS-CoV-2ZIAAI001270 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI NOTARANGELO, LUIGI · 2020 to 2025
$1.2M
Primary Immune Regulatory Disorders (PIRD): Longitudinal Study of Clinical Presentation, Treatment and OutcomesZIAAI001376 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI DELMONTE, OTTAVIA · 2024 to 2025
$219k
NIAID NIH HHS R24 AI171055
6 · The paper itself

Abstract

backgroundThe CDC and ACIP recommend COVID-19 vaccination for patients with inborn errors of immunity (IEI). Not much is known about vaccine safety in IEI, and whether vaccination attenuates infection severity in IEI.

objectiveTo estimate COVID-19 vaccination safety and examine effect on outcomes in patients with IEI.

methodsWe built a secure registry database in conjunction with the US Immunodeficiency Network to examine vaccination frequency and indicators of safety and effectiveness in IEI patients. The registry opened on January 1, 2022, and closed on August 19, 2022.

resultsPhysicians entered data on 1245 patients from 24 countries. The most common diagnoses were antibody deficiencies (63.7%). At least one COVID-19 vaccine was administered to 806 patients (64.7%), and 216 patients received vaccination prior to the development of COVID-19. The most common vaccines administered were mRNA-based (84.0%). Seventeen patients were reported to seek outpatient clinic or emergency room care for a vaccine-related complication, and one patient was hospitalized for symptomatic anemia. Eight hundred twenty-three patients (66.1%) experienced COVID-19 infection. Of these, 156 patients required hospitalization (19.0%), 47 required ICU care (5.7%), and 28 died (3.4%). Rates of hospitalization (9.3% versus 24.4%, p < 0.001), ICU admission (2.8% versus 7.6%, p = 0.013), and death (2.3% versus 4.3%, p = 0.202) in patients who had COVID-19 were lower in patients who received vaccination prior to infection. In adjusted logistic regression analysis, not having at least one COVID-19 vaccine significantly increased the odds of hospitalization and ICU admission.

conclusionVaccination for COVID-19 in the IEI population appears safe and attenuates COVID-19 severity.

Indexed as

COVID-19COVID-19 VaccinesCritical CareHospitalizationHumansVaccinationCOVID-19 VaccinesImmunizationImmunodeficiencyOutcomesViruses: respiratory diseases

Identifiers

PMID38578389
PMCPMC10997719
OpenAlexW4393986883

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.