Evidence map›Paper›PMID 38578356›Full record

ArticleMolecular neurobiology2024

Astaxanthin and DHA Supplementation Modulates the Maternal Undernutrition-induced Impairment of Cognitive Behavior and Synaptic Plasticity in Adult Life of Offspring's -Exploring the Molecular Mechanism.

Megha Bhat Agni, Pramukh Subrahmanya Hegde, Praveen Rai, Monika Sadananda, Damodara Gowda K M

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In one paragraph

Article in Molecular neurobiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
11.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Megha Bhat AgniNitte (Deemed to be University), Department of Physiology, KS Hegde Medical Academy, Deralakatte, Mangalore, Karnataka, 575018, India.ORCID https://orcid.org/0000-0003-1139-3332
Pramukh Subrahmanya HegdeNitte (Deemed to be University), Department of Physiology, KS Hegde Medical Academy, Deralakatte, Mangalore, Karnataka, 575018, India.ORCID https://orcid.org/0000-0001-9808-1571
Praveen RaiNitte (Deemed to be University), Department of Infectious Diseases & Microbial Genomics, Nitte University Centre for Science Education and Research (NUCSER), Mangalore, Karnataka, 575018, India.ORCID https://orcid.org/0000-0002-3695-4178
Monika SadanandaBiotechnology Unit, Department of Biosciences, Mangalore University, Mangalagangothri, 574199, Karnataka, India.ORCID https://orcid.org/0000-0002-1696-212X
Damodara Gowda K MNitte (Deemed to be University), Department of Physiology, KS Hegde Medical Academy, Deralakatte, Mangalore, Karnataka, 575018, India. dr_damodar@nitte.edu.in.ORCID https://orcid.org/0000-0002-2552-2177
K S Hegde Medical Academy · INMangalore University · INNitte University · IN

Funding

Indian Council of Medical Research No. 5/9/1220/2019-Nut.
6 · The paper itself

Abstract

Maternal nutrition was recognized as a significant part of brain growth and maturation in most mammalian species. Timely intervention with suitable nutraceuticals would provide long-term health benefits. We aim to unravel the molecular mechanisms of perinatal undernutrition-induced impairments in cognition and synaptic plasticity, employing animal model based on dietary nutraceutical supplementation. We treated undernourished dams at their gestational, lactational, and at both the time point with Astaxanthin (AsX) and Docosahexaenoic acid (DHA), and their pups were used as experimental animals. We evaluated the cognitive function by subjecting the pups to behavioral tests in their adult life. In addition, we assessed the expression of genes in the hippocampus related to cognitive function and synaptic plasticity. Our results showed downregulation of Brain-derived neurotrophic factor (BDNF), Neurotrophin-3 (NT-3), cAMP response-element-binding protein (CREB), and uncoupling protein-2 (UCP2) gene expression in pups born to undernourished dams in their adult life, which AsX and DHA modulated. Maternal AsX and DHA supplementation ameliorated the undernutrition-induced learning impairment in novel object recognition (NOR) tests and partially baited radial arm maze (RAM) tasks in offspring's. The expressions of Synapsin-1 and PSD-95 decreased in perinatally undernourished groups compared to control and AsX-DHA treated groups at CA1, CA2, CA3, and DG. AsX and DHA supplementation upregulated BDNF, NT-3, CREB, and UCP2 gene expressions in perinatally undernourished rats, which are involved in intracellular signaling cascades like Ras, PI3K, and PLC. The results of our study give new insights into neuronal differentiation, survival, and plasticity, indicating that the perinatal period is the critical time for reversing maternal undernutrition-induced cognitive impairment in offspring's.

Indexed as

Dietary SupplementsDocosahexaenoic AcidsMalnutritionNeuronal PlasticityXanthophyllsAnimalsAnimals, NewbornBehavior, AnimalCognitionFemaleHippocampusMaleMaternal Nutritional Physiological PhenomenaPregnancyPrenatal Exposure Delayed EffectsRats, WistarastaxanthineDocosahexaenoic AcidsXanthophyllsAstaxanthinDocosahexaenoic acidHippocampusMaternal undernutritionRecognition memorySpatial learning and memorySynaptic Plasticity

Identifiers

PMID38578356
OpenAlexW4393992709

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.