Evidence map›Paper›PMID 38578207›Full record

ReviewRadiology. Imaging cancer2024

An Update on MR Spectroscopy in Cancer Management: Advances in Instrumentation, Acquisition, and Analysis.

Eva Martinez Luque, Zexuan Liu, Dongsuk Sung, Rachel M Goldberg, Rishab Agarwal, Aditya Bhattacharya, Nadine S Ahmed, Jason W Allen, Candace C Fleischer

Open access · diamondAbstract readReview
In one paragraph

Review in Radiology. Imaging cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Multi-Vendor and Multi-Site Characterization ofMagnetic resonance in medicine · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Eva Martinez LuqueFrom the Departments of Radiology and Imaging Sciences (E.M.L., Z.L., D.S., J.W.A., C.C.F.) and Neurology (J.W.A.), Emory University School of Medicine, Atlanta, Ga; Department of Biomedical Engineering (E.M.L., Z.L., D.S., J.W.A., C.C.F.), Georgia Institute of Technology and Emory University, Atlanta, Ga; College of Arts and Sciences, Emory University, Atlanta, Ga (R.M.G.); and College of Business (R.A.) and College of Sciences (A.B., N.S.A.), Georgia Institute of Technology, Atlanta, Georgia.ORCID 0000-0002-0521-6877
Zexuan LiuFrom the Departments of Radiology and Imaging Sciences (E.M.L., Z.L., D.S., J.W.A., C.C.F.) and Neurology (J.W.A.), Emory University School of Medicine, Atlanta, Ga; Department of Biomedical Engineering (E.M.L., Z.L., D.S., J.W.A., C.C.F.), Georgia Institute of Technology and Emory University, Atlanta, Ga; College of Arts and Sciences, Emory University, Atlanta, Ga (R.M.G.); and College of Business (R.A.) and College of Sciences (A.B., N.S.A.), Georgia Institute of Technology, Atlanta, Georgia.ORCID 0000-0001-7463-1612
Dongsuk SungFrom the Departments of Radiology and Imaging Sciences (E.M.L., Z.L., D.S., J.W.A., C.C.F.) and Neurology (J.W.A.), Emory University School of Medicine, Atlanta, Ga; Department of Biomedical Engineering (E.M.L., Z.L., D.S., J.W.A., C.C.F.), Georgia Institute of Technology and Emory University, Atlanta, Ga; College of Arts and Sciences, Emory University, Atlanta, Ga (R.M.G.); and College of Business (R.A.) and College of Sciences (A.B., N.S.A.), Georgia Institute of Technology, Atlanta, Georgia.ORCID 0000-0001-6287-2144
Rachel M GoldbergFrom the Departments of Radiology and Imaging Sciences (E.M.L., Z.L., D.S., J.W.A., C.C.F.) and Neurology (J.W.A.), Emory University School of Medicine, Atlanta, Ga; Department of Biomedical Engineering (E.M.L., Z.L., D.S., J.W.A., C.C.F.), Georgia Institute of Technology and Emory University, Atlanta, Ga; College of Arts and Sciences, Emory University, Atlanta, Ga (R.M.G.); and College of Business (R.A.) and College of Sciences (A.B., N.S.A.), Georgia Institute of Technology, Atlanta, Georgia.ORCID 0009-0004-1959-749X
Rishab AgarwalFrom the Departments of Radiology and Imaging Sciences (E.M.L., Z.L., D.S., J.W.A., C.C.F.) and Neurology (J.W.A.), Emory University School of Medicine, Atlanta, Ga; Department of Biomedical Engineering (E.M.L., Z.L., D.S., J.W.A., C.C.F.), Georgia Institute of Technology and Emory University, Atlanta, Ga; College of Arts and Sciences, Emory University, Atlanta, Ga (R.M.G.); and College of Business (R.A.) and College of Sciences (A.B., N.S.A.), Georgia Institute of Technology, Atlanta, Georgia.ORCID 0009-0000-3238-2590
Aditya BhattacharyaFrom the Departments of Radiology and Imaging Sciences (E.M.L., Z.L., D.S., J.W.A., C.C.F.) and Neurology (J.W.A.), Emory University School of Medicine, Atlanta, Ga; Department of Biomedical Engineering (E.M.L., Z.L., D.S., J.W.A., C.C.F.), Georgia Institute of Technology and Emory University, Atlanta, Ga; College of Arts and Sciences, Emory University, Atlanta, Ga (R.M.G.); and College of Business (R.A.) and College of Sciences (A.B., N.S.A.), Georgia Institute of Technology, Atlanta, Georgia.ORCID 0009-0003-5300-6799
Nadine S AhmedFrom the Departments of Radiology and Imaging Sciences (E.M.L., Z.L., D.S., J.W.A., C.C.F.) and Neurology (J.W.A.), Emory University School of Medicine, Atlanta, Ga; Department of Biomedical Engineering (E.M.L., Z.L., D.S., J.W.A., C.C.F.), Georgia Institute of Technology and Emory University, Atlanta, Ga; College of Arts and Sciences, Emory University, Atlanta, Ga (R.M.G.); and College of Business (R.A.) and College of Sciences (A.B., N.S.A.), Georgia Institute of Technology, Atlanta, Georgia.ORCID 0009-0006-7904-5018
Jason W AllenFrom the Departments of Radiology and Imaging Sciences (E.M.L., Z.L., D.S., J.W.A., C.C.F.) and Neurology (J.W.A.), Emory University School of Medicine, Atlanta, Ga; Department of Biomedical Engineering (E.M.L., Z.L., D.S., J.W.A., C.C.F.), Georgia Institute of Technology and Emory University, Atlanta, Ga; College of Arts and Sciences, Emory University, Atlanta, Ga (R.M.G.); and College of Business (R.A.) and College of Sciences (A.B., N.S.A.), Georgia Institute of Technology, Atlanta, Georgia.ORCID 0000-0002-5274-1105
Candace C FleischerFrom the Departments of Radiology and Imaging Sciences (E.M.L., Z.L., D.S., J.W.A., C.C.F.) and Neurology (J.W.A.), Emory University School of Medicine, Atlanta, Ga; Department of Biomedical Engineering (E.M.L., Z.L., D.S., J.W.A., C.C.F.), Georgia Institute of Technology and Emory University, Atlanta, Ga; College of Arts and Sciences, Emory University, Atlanta, Ga (R.M.G.); and College of Business (R.A.) and College of Sciences (A.B., N.S.A.), Georgia Institute of Technology, Atlanta, Georgia.ORCID 0000-0003-3265-2276
Georgia Institute of Technology · US

Funding

A novel framework for quantifying metabolic brain healthDP2NS127704 · NINDS · EMORY UNIVERSITY · PI FLEISCHER, CANDACE C. · 2021 to 2024
$2.3M
NINDS NIH HHS DP2 NS127704
6 · The paper itself

Abstract

MR spectroscopy (MRS) is a noninvasive imaging method enabling chemical and molecular profiling of tissues in a localized, multiplexed, and nonionizing manner. As metabolic reprogramming is a hallmark of cancer, MRS provides valuable metabolic and molecular information for cancer diagnosis, prognosis, treatment monitoring, and patient management. This review provides an update on the use of MRS for clinical cancer management. The first section includes an overview of the principles of MRS, current methods, and conventional metabolites of interest. The remainder of the review is focused on three key areas: advances in instrumentation, specifically ultrahigh-field-strength MRI scanners and hybrid systems; emerging methods for acquisition, including deuterium imaging, hyperpolarized carbon 13 MRI and MRS, chemical exchange saturation transfer, diffusion-weighted MRS, MR fingerprinting, and fast acquisition; and analysis aided by artificial intelligence. The review concludes with future recommendations to facilitate routine use of MRS in cancer management.

Indexed as

Artificial IntelligenceNeoplasmsHumansMagnetic Resonance ImagingMagnetic Resonance SpectroscopyClinical Cancer ManagementMetabolic ReprogrammingMolecular Imaging in OncologyMR SpectroscopySpectroscopic Imaging

Identifiers

PMID38578207
PMCPMC11148681
OpenAlexW4394005742

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.