Evidence map›Paper›PMID 38578117›Full record

ArticleAnnals of neurology2024

Evaluating the Effect of Alzheimer's Disease-Related Biomarker Change in Corticobasal Syndrome and Progressive Supranuclear Palsy.

Indira Garcia-Cordero, Chloe Anastassiadis, Abeer Khoja, Alonso Morales-Rivero, Simrika Thapa, Anna Vasilevskaya, Carly Davenport, Vishaal Sumra, Blas Couto, Namita Multani and 19 more

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02966145 (The Four-Repeat Tauopathy Neuroimaging Initiative), which is not on this map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02966145 completednot on this map

The Four-Repeat Tauopathy Neuroimaging Initiative

TypeobservationalSponsorUniversity of California, San FranciscoRan2016 to 2024Enrolled293ConditionsCorticobasal Degeneration (CBD), Corticobasal Syndrome (CBS), Cortical-basal Ganglionic Degeneration (CBGD), Progressive Supranuclear Palsy (PSP)ArmsObservational Study
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Decade-Long Prodrome on Neuroimaging: Unique Insight into Probable Corticobasal Degeneration.Movement disorders : official journal of the Movement Disorder Society · 2025
    Article
  7. Language impairment is associated with faster progression in progressive supranuclear palsy-Richardson syndrome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Clinical and neuropathological associations of plasma AβAlzheimer's & dementia (Amsterdam, Netherlands)
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors at 8 institutions in 5 countries.

Indira Garcia-CorderoTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.ORCID 0000-0001-9739-5018
Chloe AnastassiadisTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.
Abeer KhojaUniversity Health Network Memory Clinic, Toronto, ON, Canada.
Alonso Morales-RiveroUniversity Health Network Memory Clinic, Toronto, ON, Canada.
Simrika ThapaTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.
Anna VasilevskayaTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.
Carly DavenportTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.
Vishaal SumraTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.ORCID 0000-0002-4521-792X
Blas CoutoRossy PSP Program, University Health Network and the University of Toronto, Toronto, ON, Canada.
Namita MultaniTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.
Foad TaghdiriTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.ORCID 0000-0002-3280-2804
Cassandra AnorTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.
Karen MisquittaTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.
Lawren VandevredeMemory and Aging Center, Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, CA, USA.
Hilary HeuerMemory and Aging Center, Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, CA, USA.
David Tang-WaiKrembil Brain Institute, University Health Network, Toronto, ON, Canada.
Bradford DickersonAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Alexander PantelyatDepartment of Neurology, John Hopkins University, Baltimore, MD, USA.
Irene LitvanDepartment of Neurosciences, University of California San Diego, La Jolla, CA, USA.
Bradley BoeveDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Julio C RojasMemory and Aging Center, Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, CA, USA.
Peter LjubenkovMemory and Aging Center, Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, CA, USA.
Edward HueyDepartment of Psychiatry and Human Behavior, Brown University, Providence, RI, USA.
Susan FoxRossy PSP Program, University Health Network and the University of Toronto, Toronto, ON, Canada.
Gabor G KovacsTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.
Adam BoxerMemory and Aging Center, Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, CA, USA.
Anthony LangTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.
M Carmela TartagliaTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.ORCID 0000-0002-5944-8497
4‐R‐Tauopathy Neuroimaging Initiative Consortium, and the Alzheimer's Disease Neuroimaging Initiative
University of Toronto · CAUniversity Health Network · CAUniversity of California, San Francisco · USBrown University · USHarvard University · USJohns Hopkins University · USMayo Clinic in Arizona · USUniversity of California San Diego · US

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
Research Education ComponentP30AG066507 · NIA · JOHNS HOPKINS UNIVERSITY · PI Corinne Pettigrew · 2020 to 2026
$29.3M
The Four Repeat Tauopathy Neuroimaging InitiativeR01AG038791 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BOXER, ADAM L. · 2010 to 2020
$18.1M
Genetic basis of neuropsychiatric symptoms in Alzheimer's diseaseU01AG079850 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Gary Wayne Beecham, Edward D Huey · 2023 to 2026
$3.0M
Neuroanatomical associations with the factor structure underlying neuropsychiatric symptoms in Alzheimer's diseaseR01AG062268 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HUEY, EDWARD D · 2018 to 2022
$2.5M
Using RDoC Negative and Positive Valence Paradigms to Investigate the Mechanisms of Neuropsychiatric Symptoms (NPS) in Alzheimer's Disease and Related DementiasR01MH120794 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HUEY, EDWARD D · 2019 to 2023
$2.1M
Proteomics for fluid biomarker discovery in frontotemporal dementiaK23AG059888 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROJAS-MARTINEZ, JULIO CESAR · 2019 to 2023
$995k
Multi-modal magnetic resonance imaging in progressive supranuclear palsy (PSP)K23AG059891 · NIA · JOHNS HOPKINS UNIVERSITY · PI PANTELYAT, ALEXANDER Y. · 2018 to 2022
$968k
Alzheimer's AssociationAlzheimer's Society of CanadaAssociation for Frontotemporal DegenerationCIHRCLC NIH HHSNIA NIH HHS K23 AG059888NIA NIH HHS K23 AG059891NIA NIH HHS P30 AG066507NIA NIH HHS R01 AG038791NIA NIH HHS R01 AG062268NIA NIH HHS U01 AG024904NIA NIH HHS U01 AG079850NIMH NIH HHS R01 MH120794
6 · The paper itself

Abstract

objectivesTo evaluate the effect of Alzheimer's disease (AD) -related biomarker change on clinical features, brain atrophy and functional connectivity of patients with corticobasal syndrome (CBS) and progressive supranuclear palsy (PSP).

methodsData from patients with a clinical diagnosis of CBS, PSP, and AD and healthy controls were obtained from the 4-R-Tauopathy Neuroimaging Initiative 1 and 2, the Alzheimer's Disease Neuroimaging Initiative, and a local cohort from the Toronto Western Hospital. Patients with CBS and PSP were divided into AD-positive (CBS/PSP-AD) and AD-negative (CBS/PSP-noAD) groups based on fluid biomarkers and amyloid PET scans. Cognitive, motor, and depression scores; AD fluid biomarkers (cerebrospinal p-tau, t-tau, and amyloid-beta, and plasma ptau-217); and neuroimaging data (amyloid PET, MRI and fMRI) were collected. Clinical features, whole-brain gray matter volume and functional networks connectivity were compared across groups.

resultsData were analyzed from 87 CBS/PSP-noAD and 23 CBS/PSP-AD, 18 AD, and 30 healthy controls. CBS/PSP-noAD showed worse performance in comparison to CBS/PSP-AD in the PSPRS [mean(SD): 34.8(15.8) vs 23.3(11.6)] and the UPDRS scores [mean(SD): 34.2(17.0) vs 21.8(13.3)]. CBS/PSP-AD demonstrated atrophy in AD signature areas and brainstem, while CBS/PSP-noAD patients displayed atrophy in frontal and temporal areas, globus pallidus, and brainstem compared to healthy controls. The default mode network showed greatest disconnection in CBS/PSP-AD compared with CBS/PSP-no AD and controls. The thalamic network connectivity was most affected in CBS/PSP-noAD.

interpretationAD biomarker positivity may modulate the clinical presentation of CBS/PSP, with evidence of distinctive structural and functional brain changes associated with the AD pathology/co-pathology. ANN NEUROL 2024;96:99-109.

Indexed as

Alzheimer DiseaseBiomarkersSupranuclear Palsy, ProgressiveAgedAmyloid beta-PeptidesAtrophyBrainCorticobasal DegenerationFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedPositron-Emission Tomographytau ProteinsAmyloid beta-PeptidesBiomarkerstau Proteins

Identifiers

PMID38578117
PMCPMC11249787
OpenAlexW4393992998

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.