Evidence map›Paper›PMID 38577941›Full record

ArticleInternational journal of oncology2024

Knockdown of PGBD5 inhibits the malignant progression of glioma through upregulation of the PPAR pathway.

Pengren Luo, Jinhong Yang, Lipeng Jian, Jigen Dong, Shi Yin, Chao Luo, Shuai Zhou

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Pengren Luo *Department of Neurosurgery, The First People's Hospital of Yunnan Province, Kunming, Yunnan 650500, P.R. China.
Jinhong Yang *Medical School, Kunming University of Science and Technology, Kunming, Yunnan 650500, P.R. China.
Lipeng JianDepartment of Neurosurgery, The First People's Hospital of Yunnan Province, Kunming, Yunnan 650500, P.R. China.
Jigen DongDepartment of Neurosurgery, The First People's Hospital of Yunnan Province, Kunming, Yunnan 650500, P.R. China.
Shi YinDepartment of Neurosurgery, The First People's Hospital of Yunnan Province, Kunming, Yunnan 650500, P.R. China.
Chao LuoDepartment of Neurosurgery, The First People's Hospital of Yunnan Province, Kunming, Yunnan 650500, P.R. China.
Shuai ZhouDepartment of Neurosurgery, The First People's Hospital of Yunnan Province, Kunming, Yunnan 650500, P.R. China.
First People's Hospital of Yunnan Province · CNKunming University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioma is the most common type of primary intracranial malignant tumor, and because of its high invasiveness and recurrence, its prognosis remains poor. The present study investigated the biological function of piggyBac transportable element derived 5 (PGBD5) in glioma. Glioma and para-cancerous tissues were obtained from five patients. Reverse transcription-quantitative PCR and western blotting were used to detect the expression levels of PGBD5. Transwell assay and flow cytometry were used to evaluate cell migration, invasion, apoptosis and cell cycle distribution. In addition, a nude mouse tumor transplantation model was established to study the downstream pathways of PGBD5 and the molecular mechanism was analyzed using transcriptome sequencing. The mRNA and protein expression levels of PGBD5 were increased in glioma tissues and cells. Notably, knockdown of PGBD5

Indexed as

Brain NeoplasmsGliomaAnimalsApoptosisCell Line, TumorCell MovementCell ProliferationGene Expression Regulation, NeoplasticHumansMiceNeoplasm InvasivenessPeroxisome Proliferator-Activated ReceptorsTranscription FactorsTransposasesUp-RegulationPeroxisome Proliferator-Activated ReceptorsPGBD5 protein, humanTranscription FactorsTransposasesgliomaPGBD5PPAR signalingtransposonstumor growth

Identifiers

PMID38577941
PMCPMC11015917
OpenAlexW4393987994

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.