ArticleCancer reports (Hoboken, N.J.)2024
A case report of prostate cancer with leptomeningeal metastasis and bone marrow involvement.
Article in Cancer reports (Hoboken, N.J.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Dural Metastasis of Prostatic Adenocarcinoma Mimicking Meningioma en Plaque: Case Report and Systematic Review.Cureus · 2026Article
- Extra-axial small cell prostate carcinoma intracranial metastasis: illustrative case.Journal of neurosurgery. Case lessons · 2025Article
- A case report of prostate cancer with leptomeningeal metastasis and bone marrow involvement.Cancer reports (Hoboken, N.J.) · 2024Article
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Authors and funding
7 authors.
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Abstract
backgroundProstate cancer is the second most common cancer in men. Central nervous system (CNS) involvement in prostate cancer which manifests as cerebral, leptomeningeal, or dural involvement is uncommon and occurs late in the course of disease. CASE: A 60-year-old patient with castration resistant prostate cancer (CRPC) presented with headache and fatigue. Evaluation revealed bone marrow and leptomeningeal involvement. The patient treated by whole brain radiotherapy, leuprolide, weekly docetaxel and daily 1000 mg abiraterone. Complete blood count (CBC) and CNS symptoms improved and the patient is alive after 11 months with excellent performance status.
conclusionLeptomeningeal involvement in prostate cancer is rare and is associated with a poor prognosis but the possibility of such event should be considered in patients with new onset progressive CNS symptoms. New treatment strategies such as combination of docetaxel and abiraterone added to androgen deprivation therapy (triplet therapy) might improve outcome in these patients.
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