ArticleEpigenetics2024
Trauma context exerts intergenerational effects on child mental health via DNA methylation.
Article in Epigenetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Population epigenetics: deciphering DNA methylation diversity and its implications for health, disease, and evolution.Molecular biology and evolution · 2026Review
- Sex Differences in the Interaction of Epigenetic Risk and Trajectories of Default Mode Limbic Network Integration Predicting Childhood Anxiety.Research square · 2026Article
- Cumulative Stress Burden and Association With DNA Methylation in Ethiopian American Immigrants: Protocol for a Community-Engaged, Biopsychosocial Study.JMIR research protocols · 2026Article
- Epigenetic age and neurodevelopmental outcomes in children born preterm.Genetics in medicine open · 2026Article
- Epigenetics of Childhood Obesity.Hormone research in paediatrics · 2026Review
- Biological research involving people with lived experience of childhood trauma: a trauma-informed approach.Frontiers in psychology · 2026Article
- Integrative DNA methylation and transcriptome analysis reveal cell-type specific patterns in response to elevated allostatic load.Epigenetics · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Many people experience traumatic or negative events, but few develop mental health issues as a result. This study investigated whether newborn DNA methylation (DNAm) previously associated with maternal childhood physical abuse by her father affected the child's mental health and physical growth, as well as whether it mediated or moderated developmental outcomes.
methodsStudy sample (
resultsFull cohort analyses showed that newborn DNAm of several different CpG sites associates with separation anxiety, fear, and unhappy/tearful presentations in children aged 6-7 y. Sex-specific associations emerged with boys showing associations with anxiety and fear, and girls showing associations with fear and unhappiness. In boys only, cord blood DNAm mediates the effect of maternal childhood trauma on offspring mental health. No moderation effects emerged.
conclusionIntergenerational effects of mother's relationship to her abuser present in newborn DNAm associate with 7-year-old child's mental health, show sex-specific effects, and newborn DNAm does mediate maternal childhood trauma effects on offspring mental health in early-life.
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