Evidence map›Paper›PMID 38577521›Full record

ArticleJBMR plus2024

Wnt pathway inhibition with the porcupine inhibitor LGK974 decreases trabecular bone but not fibrosis in a murine model with fibrotic bone.

Hsuan Lung, Kelly L Wentworth, Tania Moody, Ariane Zamarioli, Apsara Ram, Gauri Ganesh, Misun Kang, Sunita Ho, Edward C Hsiao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JBMR plus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Wnt5a-mediated Adipo-Cardiac Interorgan Communication in HFpEF.bioRxiv : the preprint server for biology · 2025
    Article
  4. Article
  5. Article
  6. Update on the medical management of fibrous dysplasia of the bone.Therapeutic advances in endocrinology and metabolism · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Hsuan LungDepartment of Medicine, Division of Endocrinology and Metabolism, The Institute for Human Genetics, and the Eli and Edythe Broad Institute for Regeneration Medicine, University of California, San Francisco, CA 94143, United States.
Kelly L WentworthDepartment of Medicine, Division of Endocrinology and Metabolism, The Institute for Human Genetics, and the Eli and Edythe Broad Institute for Regeneration Medicine, University of California, San Francisco, CA 94143, United States.
Tania MoodyDepartment of Medicine, Division of Endocrinology and Metabolism, The Institute for Human Genetics, and the Eli and Edythe Broad Institute for Regeneration Medicine, University of California, San Francisco, CA 94143, United States.
Ariane ZamarioliDepartment of Medicine, Division of Endocrinology and Metabolism, The Institute for Human Genetics, and the Eli and Edythe Broad Institute for Regeneration Medicine, University of California, San Francisco, CA 94143, United States.
Apsara RamDepartment of Medicine, Division of Endocrinology and Metabolism, The Institute for Human Genetics, and the Eli and Edythe Broad Institute for Regeneration Medicine, University of California, San Francisco, CA 94143, United States.
Gauri GaneshDepartment of Medicine, Division of Endocrinology and Metabolism, The Institute for Human Genetics, and the Eli and Edythe Broad Institute for Regeneration Medicine, University of California, San Francisco, CA 94143, United States.
Misun KangOral and Craniofacial Sciences Graduate Program, School of Dentistry, University of California, San Francisco, CA 94143, United States.
Sunita HoOral and Craniofacial Sciences Graduate Program, School of Dentistry, University of California, San Francisco, CA 94143, United States.
Edward C HsiaoDepartment of Medicine, Division of Endocrinology and Metabolism, The Institute for Human Genetics, and the Eli and Edythe Broad Institute for Regeneration Medicine, University of California, San Francisco, CA 94143, United States.
Broad Institute · USUniversity of California, San Francisco · USBroad Center · USChang Gung University · TWSan Francisco General Hospital · US

Funding

Skeletal Biology and Biomechanics (SBB) CoreP30AR075055 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI EDWARD C HSIAO · 2019 to 2026
$7.1M
Load-mediated Adaptation of the Bone-PDL-Tooth Complex in VertebratesR01DE022032 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HO, SUNITA P · 2012 to 2021
$3.4M
Dissecting the Cellular and Molecular Mechanisms Contributing to Craniofacial Fibrous DysplasiaK08DE028946 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WENTWORTH, KELLY LEE · 2019 to 2023
$860k
Regulation of Bone Formation by G-protein SignalingK08AR056299 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HSIAO, EDWARD C · 2009 to 2013
$640k
Pressure-inducer and Sensor to Map Dynamic Periodontal Mechanobiological ActivityR21DE027138 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HO, SUNITA P · 2017 to 2018
$436k
A Human Pluripotent Stem Cell Model for Elucidating Cell Fate Defects in McCune-Albright SyndromeF32HD091025 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WENTWORTH, KELLY LEE · 2017 to 2018
$137k
NIAMS NIH HHS K08 AR056299NIAMS NIH HHS P30 AR075055NICHD NIH HHS F32 HD091025NIDCR NIH HHS K08 DE028946NIDCR NIH HHS L30 DE029063NIDCR NIH HHS R01 DE022032NIDCR NIH HHS R21 DE027138
6 · The paper itself

Abstract

G protein-coupled receptors (GPCRs) mediate a wide spectrum of physiological functions, including the development, remodeling, and repair of the skeleton. Fibrous dysplasia (FD) of the bone is characterized by fibrotic, expansile bone lesions caused by activating mutations in

Indexed as

fibrotic bone diseasefibrous dysplasia (FD)GnasGPCRG-protein coupled receptor signalingGsαosteoblaststrabecular boneWnt pathway inhibition

Identifiers

PMID38577521
PMCPMC10994528
OpenAlexW4391061720

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.