Evidence map›Paper›PMID 38577466›Full record

ArticleWorld journal of gastrointestinal oncology2024

High patatin like phospholipase domain containing 8 expression as a biomarker for poor prognosis of colorectal cancer.

Peng-Yang Zhou, De-Xiang Zhu, Yi-Jiao Chen, Qing-Yang Feng, Yi-Hao Mao, Ao-Bo Zhuang, Jian-Min Xu

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastrointestinal oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 95% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Peng-Yang ZhouDepartment of General Surgery, Zhongshan Hospital Fudan University, Shanghai 200032, China.
De-Xiang ZhuDepartment of General Surgery, Zhongshan Hospital Fudan University, Shanghai 200032, China.
Yi-Jiao ChenDepartment of General Surgery, Zhongshan Hospital Fudan University, Shanghai 200032, China.
Qing-Yang FengDepartment of General Surgery, Zhongshan Hospital Fudan University, Shanghai 200032, China.
Yi-Hao MaoDepartment of General Surgery, Zhongshan Hospital Fudan University, Shanghai 200032, China.
Ao-Bo ZhuangDepartment of General Surgery, Zhongshan Hospital Fudan University, Shanghai 200032, China.
Jian-Min XuDepartment of General Surgery, Zhongshan Hospital Fudan University, Shanghai 200032, China. xujmin@aliyun.com.
Fudan University · CNThe First Affiliated Hospital, Sun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatatin like phospholipase domain containing 8 (PNPLA8) has been shown to play a significant role in various cancer entities. Previous studies have focused on its roles as an antioxidant and in lipid peroxidation. However, the role of PNPLA8 in colorectal cancer (CRC) progression is unclear.

aimTo explore the prognostic effects of PNPLA8 expression in CRC.

methodsA retrospective cohort containing 751 consecutive CRC patients was enrolled. PNPLA8 expression in tumor samples was evaluated by immunohistochemistry staining and semi-quantitated with immunoreactive scores. CRC patients were divided into high and low PNPLA8 expression groups based on the cut-off values, which were calculated by X-tile software. The prognostic value of PNPLA8 was identified using univariate and multivariate Cox regression analysis. The overall survival (OS) rates of CRC patients in the study cohort were compared with Kaplan-Meier analysis and Log-rank test.

resultsPNPLA8 expression was significantly associated with distant metastases in our cohort (

conclusionPNPLA8 is a novel independent prognostic factor for CRC. These findings suggest that PNPLA8 is a potential target in clinical CRC management.

Indexed as

BiomarkerColorectal cancerExpression levelOverall survivalPatatin like phospholipase domain containing 8Prognosis

Identifiers

PMID38577466
PMCPMC10989391
OpenAlexW4392727203

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