ArticleWorld journal of gastrointestinal surgery2024
Impact of frailty on short-term postoperative outcomes in patients undergoing colorectal cancer surgery: A systematic review and meta-analysis.
Article in World journal of gastrointestinal surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 12 citations in OpenAlex.
- Impact of frailty on postoperative delirium in ICU patients aged 65 and older: a systematic review.BMJ open · 2026Pooled it
- Impact of frailty on outcomes of pancreatic surgery: a systematic review and meta-analysis.Frontiers in nutrition · 2026Pooled it
- Perioperative neurocognitive disorder in colorectal cancer surgery: a systematic review of incidence, mechanisms, and interventions.Frontiers in surgery · 2025Pooled it
- Chronological age and failure to rescue after colorectal cancer surgery: A multicentre cohort study.Aging clinical and experimental research · 2026Article
- One-Year Changes in Frailty Components After Curative Minimally Invasive Surgery for Colorectal Cancer in Older Patients.Annals of gastroenterological surgery · 2026Article
- Prehabilitation and postoperative outcomes in colorectal surgery: an umbrella review.Journal of anesthesia, analgesia and critical care · 2026Review
- Article
- Mild to moderate frailty among older adults does not affect long-term quality of life or functional outcomes after colon cancer surgery.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2026Observational
- Relationship between preoperative modified frailty index, immune-inflammation index, and outcomes of colorectal cancer surgery in older patients.World journal of gastrointestinal oncology · 2026Article
- Preoperative social frailty and short-term postoperative outcomes in gastrointestinal cancer surgery: a multicentre prospective cohort study in China.World journal of surgical oncology · 2026Observational
- Frailty Recovery Following Minimally Invasive Surgery: An Emerging Perspective on Surgical Benefits in Elderly Colorectal Cancer Patients.Annals of gastroenterological surgery · 2026Article
- Frailty phenotype and long-term mortality after curative colorectal cancer surgery: a retrospective multicenter cohort study.Frontiers in oncology · 2026Article
- Postoperative delirium in patients with cancer: a narrative review of major risk factors.Sao Paulo medical journal = Revista paulista de medicina · 2026Review
- Significance of Naples prognostic score for postoperative complications after colorectal cancer surgery.Surgery today · 2025Article
- Frailty, Comorbidities, and In-Hospital Outcomes in Older Cholangiocarcinoma Patients.Journal of clinical medicine · 2025Article
- Association of Preoperative Frailty in Older Taiwanese Patients with Colorectal Cancer.Risk management and healthcare policy · 2025Article
- Surgery Reduces Cancer-specific Death in Elderly Right-Sided Colon Cancer: A SEER-Based Competing-Risk Analysis.Cancer control : journal of the Moffitt Cancer CenterArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundColorectal cancer is a major global health challenge that predominantly affects older people. Surgical management, despite advancements, requires careful consideration of preoperative patient status for optimal outcomes.
aimTo summarize existing evidence on the association of frailty with short-term postoperative outcomes in patients undergoing colorectal cancer surgery.
methodsA literature search was conducted using PubMed, EMBASE and Scopus databases for observational studies in adult patients aged ≥ 18 years undergoing planned or elective colorectal surgery for primary carcinoma and/or secondary metastasis. Only studies that conducted frailty assessment using recognized frailty assessment tools and had a comparator group, comprising nonfrail patients, were included. Pooled effect sizes were reported as weighted mean difference or relative risk (RR) with 95% confidence intervals (CIs).
resultsA total of 24 studies were included. Compared with nonfrail patients, frailty was associated with an increased risk of mortality at 30 d (RR: 1.99, 95%CI: 1.47-2.69), at 90 d (RR: 4.76, 95%CI: 1.56-14.6) and at 1 year (RR: 5.73, 95%CI: 2.74-12.0) of follow up. Frail patients had an increased risk of any complications (RR: 1.81, 95%CI: 1.57-2.10) as well as major complications (Clavien-Dindo classification grade ≥ III) (RR: 2.87, 95%CI: 1.65-4.99) compared with the control group. The risk of reoperation (RR: 1.18, 95%CI: 1.07-1.31), readmission (RR: 1.70, 95%CI: 1.36-2.12), need for blood transfusion (RR: 1.67, 95%CI: 1.52-1.85), wound complications (RR: 1.49, 95%CI: 1.11-1.99), delirium (RR: 4.60, 95%CI: 2.31-9.16), risk of prolonged hospitalization (RR: 2.09, 95%CI: 1.22-3.60) and discharge to a skilled nursing facility or rehabilitation center (RR: 3.19, 95%CI: 2.0-5.08) was all higher in frail patients.
conclusionFrailty in colorectal cancer surgery patients was associated with more complications, longer hospital stays, higher reoperation risk, and increased mortality. Integrating frailty assessment appears crucial for tailored surgical management.
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