Evidence map›Paper›PMID 38577066›Full record

ArticleEnvironmental science. Nano2024

House Dust Mite Extract Forms a Der p 2 Corona on Multi-Walled Carbon Nanotubes: Implications for Allergic Airway Disease.

Judith Dominguez, Samantha K Holmes, Ryan D Bartone, Logan J Tisch, Robert M Tighe, James C Bonner, Christine K Payne

Open access · greenAbstract read
In one paragraph

Article in Environmental science. Nano, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Adverse effects of nanoparticles on humans.Journal of occupational health · 2025
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Judith DominguezThomas Lord Department of Mechanical Engineering and Materials Science, Duke University, Durham, North Carolina, USA 27708.
Samantha K HolmesThomas Lord Department of Mechanical Engineering and Materials Science, Duke University, Durham, North Carolina, USA 27708.
Ryan D BartoneToxicology Program, Department of Biological Sciences, North Carolina State University, Raleigh, North Carolina, USA 27695.
Logan J TischToxicology Program, Department of Biological Sciences, North Carolina State University, Raleigh, North Carolina, USA 27695.
Robert M TigheDepartment of Medicine, Duke University School of Medicine, Durham, North Carolina, USA 27710.
James C BonnerToxicology Program, Department of Biological Sciences, North Carolina State University, Raleigh, North Carolina, USA 27695.
Christine K PayneThomas Lord Department of Mechanical Engineering and Materials Science, Duke University, Durham, North Carolina, USA 27708.
Duke University · USNorth Carolina State University · US

Funding

TRAINING IN BIOCHEMICAL AND ENVIRONMENTAL TOXICOLOGYT32ES007046 · NIEHS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI Seth William Kullman · 1985 to 2026
$5.1M
Mechanisms of Nanoparticle Modulation of Allergic Lung DiseaseR01ES032443 · NIEHS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI BONNER, JAMES CHRISTOPHER · 2021 to 2025
$2.2M
NIEHS NIH HHS R01 ES032443NIEHS NIH HHS T32 ES007046
6 · The paper itself

Abstract

Multi-walled carbons nanotubes (MWCNTs) are used in materials for the construction, automotive, and aerospace industries. Workers and consumers are exposed to these materials via inhalation. Existing recommended exposure limits are based on MWCNT exposures that do not take into account more realistic co-exposures. Our goal was to understand how a common allergen, house dust mites, interacts with pristine MWCNTs and lung fluid proteins. We used gel electrophoresis, western blotting, and proteomics to characterize the composition of the allergen corona formed from house dust mite extract on the surface of MWCNTs. We found that the corona is dominated by der p 2, a protein associated with human allergic responses to house dust mites. Der p 2 remains adsorbed on the surface of the MWCNTs following subsequent exposures to lung fluid proteins. The high concentration of der p 2, localized on surface of MWCNTs, has important implications for house dust mite-induced allergies and asthma. This research provides a detailed characterization of the complex house dust mite-lung fluid protein coronas for future cellular and

Identifiers

PMID38577066
PMCPMC10990074
OpenAlexW4389782059

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.