ReviewJournal of experimental orthopaedics2024
A slight degree of osteoarthritis appears to be present after anterior cruciate ligament reconstruction compared with contralateral healthy knees at a minimum of 20 years: A systematic review of the literature.
Review in Journal of experimental orthopaedics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 6 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- No Evidence of Superior Graft Remodeling and Maturation When Adding a Lateral Extra-articular Procedure to Anterior Cruciate Ligament Reconstruction: A Systematic Review and Meta-analysis of Comparative Studies.The American journal of sports medicine · 2026Pooled it
- Simultaneous anterior cruciate ligament reconstruction with valgus high tibial osteotomy improves mid- to long-term clinical outcomes without increasing the complication rates in young anterior cruciate ligament deficient patients with varus malalignment: a systematic review and meta-analysis.Journal of orthopaedic surgery and research · 2025Pooled it
- The effect of platelet-rich plasma on clinical outcomes within two years after anterior cruciate ligament reconstruction: a systematic review and meta-analysis of randomized controlled trials.Journal of orthopaedic surgery and research · 2025Pooled it
- Pooled it
- Remnant-preserving techniques in anterior cruciate ligament reconstruction: a systematic review and meta-analysis.BMC surgery · 2025Pooled it
- Pooled it
- Non-surgical treatment of anterior cruciate ligament tears with percutaneous bone marrow concentrate and platelet products versus exercise therapy: a randomized-controlled, crossover trial with 2-year follow-up.BMC musculoskeletal disorders · 2025Trial
- Patients with previous anterior cruciate ligament reconstruction achieve equally good outcomes after total knee arthroplasty: A Swedish registry-based study of 7755 patients.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2026Article
- Increased medial anterior tibial translation and reduced tibiofemoral rotation are observed during weight bearing in anterior cruciate ligament-deficient knees: A paired within-subject imaging analysis.Journal of experimental orthopaedics · 2026Article
- Clinical outcomes of quadriceps, hamstring, and bone-patellar tendon-bone autografts for ACL reconstruction: a meta-analysis of randomized controlled trials.Knee surgery & related research · 2026Review
- Low Incidence of Osteoarthritis and Excellent Clinical Outcomes at Minimum 10 Years Following Primary Repair of the Anterior Cruciate Ligament.Orthopaedic journal of sports medicine · 2026Article
- Returning to Performance After ACL Injury in Competitive Alpine Skiing: A Scoping Review and Evidence- and Expert-Informed Practice Recommendations.Scandinavian journal of medicine & science in sports · 2026Article
- Traumatic knee injuries and career drop-outs in adolescent competitive alpine skiers aged 15-19: a longitudinal 4-year follow-up study examining rates, biomechanical injury risk factors and potential reasons for quitting.Annals of medicine · 2025Article
- Hyperuricemia is associated with altered perioperative neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and inflammatory responses in patients residing in high-altitude regions who underwent anterior cruciate ligament reconstruction: A cross-sectional study.The Journal of international medical research · 2025Article
- A novel infrapatellar fat pad preservation technique in anterior cruciate ligament reconstruction reduces postoperative pain and cartilage damage: a retrospective study.Journal of orthopaedic surgery and research · 2025Article
- Femoral tunnel widening is associated with thigh muscle weakness following anterior cruciate ligament reconstruction: A call for targeted rehabilitation.The Journal of international medical research · 2025Article
- Anterior cruciate ligament tissue stiffness and anterior tibial translation are increased in patients with medial meniscus posterior root tear.Journal of orthopaedic surgery and research · 2025Article
- Ultrasound-Based Statistical Shape Modeling for Quantifying Femoral Trochlear Bone Shape Post-ACLR.Osteoarthritis imaging · 2025Article
- Observational
- Improved sexual activity and quality of life after anterior cruciate ligament reconstruction.Annals of joint · 2025Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: The aim of the present systematic review was to quantitatively synthesize the best literature evidence regarding osteoarthritis developing after anterior cruciate ligament reconstruction (ACLR), including only studies with a follow-up duration of at least 20 years. Material and Methods: A systematic review was conducted based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines on four electronic databases (PubMed, Scopus, EMBASE and Cochrane Library). The outcome measures extracted from the studies were failure rate, subsequent knee surgery on the same knee, radiographic development of osteoarthritis measured with Kellgren-Lawrence, International Knee Documentation Committee (IKDC) radiographic score and Ahlbäck classification. The health of both the ACLR knee and the contralateral knee was compared. Results: A total of 1552 patients were included in the study, of which 1290 (83.11%) were operated on using a patellar tendon graft, 190 (12.24%) with hamstrings, 27 (1.73%) with an iliotibial band and 45 (2.89%) with patellar tendon plus a ligament augmentation device (LAD). The mean age at the time of surgery was 25.18 ± 1.91 years, and the mean follow-up time was 23.34 ± 2.56 years. Analysing IDKC Score at final follow-up, ACLR Group showed a higher degree of OA compared with contralateral healthy knee ( Conclusions: ACL reconstruction appears to result in mild osteoarthritis in the long term in most of the patients and only less than 33.2% develop a moderate to severe degree of knee OA according to IKDC radiographic score. A slight degree of osteoarthritis appears to be present in ACLR knees compared with contralateral healthy knees. Level of Evidence: Level IV.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.