Evidence map›Paper›PMID 38576961›Full record

ReviewAnnals of medicine and surgery (2012)2024

Meconium aspiration syndrome: from pathophysiology to treatment.

Gianluca Dini, Sara Ceccarelli, Federica Celi, Carla Maria Semeraro, Paolo Gorello, Alberto Verrotti

Registry-linked trialOpen access · diamondAbstract readReview
In one paragraph

Review in Annals of medicine and surgery (2012), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06972108 (Caffeine for Oxygen Dependent Meconium Aspiration Syndrome), which is not on this map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06972108 phase2not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Caffeine for Oxygen Dependent Meconium Aspiration Syndrome

TypeinterventionalSponsorUniversity of AlbertaRan2026 to 2028Enrolled20ConditionsMeconium Aspiration SyndromeArmsCaffeine citrate, Saline (NaCl 0,9 %) (placebo)
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Gianluca DiniNeonatal Intensive Care Unit, "Santa Maria" Hospital, Terni.
Sara CeccarelliNeonatal Intensive Care Unit, "Santa Maria" Hospital, Terni.
Federica CeliNeonatal Intensive Care Unit, "Santa Maria" Hospital, Terni.
Carla Maria SemeraroNeonatal Intensive Care Unit, "Santa Maria" Hospital, Terni.
Paolo GorelloDepartment of Chemistry, Biology and Biotechnology, University of Perugia, Perugia.
Alberto VerrottiDepartment of Pediatrics, University of Perugia, Perugia, Italy.
Santa Maria Nuova Hospital · ITUniversity of Perugia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Meconium aspiration syndrome (MAS) is a clinical condition characterized by respiratory distress in neonates born through meconium-stained amniotic fluid (MSAF). Despite advances in obstetric practices and perinatal care, MAS remains an important cause of morbidity and mortality in term and post-term newborns. Since the 1960s, there have been significant changes in the perinatal and postnatal management of infants born through MSAF. Routine endotracheal suctioning is no longer recommended in both vigorous and non-vigorous neonates with MSAF. Supportive care along with new treatments such as surfactant, inhaled nitric oxide, and high-frequency ventilation has significantly improved the outcome of MAS patients. However, determining the most appropriate approach for this condition continues to be a topic of debate. This review offers an updated overview of the epidemiology, etiopathogenesis, diagnosis, management, and prognosis of infants with MAS.

Indexed as

meconium aspiration syndrome (MAS)meconium-stained amniotic fluid (MSAF)newbornrespiratory distress syndrome (RDS)

Identifiers

PMID38576961
PMCPMC10990371
OpenAlexW4391820829

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.