Evidence map›Paper›PMID 38576796›Full record

ArticleBrain communications2024

Is there an immunological cross-reactivity of antibodies to the myelin oligodendrocyte glycoprotein and coronaviruses?

Kathrin Schanda, Sara Mariotto, Dagmar Rudzki, Angelika Bauer, Alessandro Dinoto, Patrizia Rossi, Sergio Ferrari, Sven Jarius, Brigitte Wildemann, Federica Boso and 6 more

Open access · goldAbstract read
In one paragraph

Article in Brain communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Treatment of post-vaccination optic neuritis: implications from the global SARS-CoV-2 vaccination effort.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 8 institutions in 3 countries.

Kathrin SchandaClinical Department of Neurology, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Sara MariottoNeurology Unit, Department of Neurosciences, Biomedicine, and Movement Sciences, University of Verona, 37100 Verona, Italy.
Dagmar RudzkiClinical Department of Neurology, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Angelika BauerInstitute of Hygiene and Medical Microbiology, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Alessandro DinotoNeurology Unit, Department of Neurosciences, Biomedicine, and Movement Sciences, University of Verona, 37100 Verona, Italy.ORCID https://orcid.org/0000-0002-3249-4792
Patrizia RossiNeurology Unit, St Bassiano Hospital, Bassano del Grappa, 36100 Vicenza, Italy.
Sergio FerrariNeurology Unit, Department of Neurosciences, Biomedicine, and Movement Sciences, University of Verona, 37100 Verona, Italy.
Sven JariusMolecular Neuroimmunology Group, Department of Neurology, University of Heidelberg, 69120 Heidelberg, Germany.
Brigitte WildemannMolecular Neuroimmunology Group, Department of Neurology, University of Heidelberg, 69120 Heidelberg, Germany.
Federica BosoNeurology Unit, Trento Hospital, Azienda Provinciale per i Servizi Sanitari (APSS) di Trento, 38122 Trento, Italy.
Bruno GiomettoNeurology Unit, Trento Hospital, Azienda Provinciale per i Servizi Sanitari (APSS) di Trento, 38122 Trento, Italy.
Daniel EngelsInstitute of Clinical Neuroimmunology, University Hospital, Ludwig-Maximilians-Universität München, 81375 Munich, Germany.
Tania KümpfelInstitute of Clinical Neuroimmunology, University Hospital, Ludwig-Maximilians-Universität München, 81375 Munich, Germany.ORCID https://orcid.org/0000-0001-7509-5268
Eva-Maria WendelDepartment of Neuropediatrics, Olgahospital/Klinikum Stuttgart, 70174 Stuttgart, Germany.
Kevin RostasyPaediatric Neurology, Witten/Herdecke University, Children's Hospital Datteln, 45711 Datteln, Germany.
Markus ReindlClinical Department of Neurology, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID https://orcid.org/0000-0003-2817-1402
Innsbruck Medical University · ATUniversity of Verona · ITHeidelberg University · DELudwig-Maximilians-Universität München · DEProvincia Autonoma di Trento · ITOlgahospital · DEOspedale San Bassiano · ITWitten/Herdecke University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent reports indicated that myelin oligodendrocyte glycoprotein antibody-associated disease might be a rare complication after severe acute respiratory syndrome coronavirus 2 infection or vaccination. It is unclear whether this is an unspecific sequel of infection or vaccination or caused by possible immunological cross-reactivity of severe acute respiratory syndrome coronavirus 2 proteins and myelin oligodendrocyte glycoprotein. The aim of this study was therefore to elucidate whether there is an immunological cross-reactivity between severe acute respiratory syndrome coronavirus 2 spike or nucleocapsid proteins and myelin oligodendrocyte glycoprotein and to explore the relation of antibody responses against myelin oligodendrocyte glycoprotein and severe acute respiratory syndrome coronavirus 2 and other coronaviruses. We analysed serum samples from patients with severe acute respiratory syndrome coronavirus 2 infection and neurological symptoms with (myelin oligodendrocyte glycoprotein antibody-associated disease,

Indexed as

antibodycross-reactivityMOGnucleocapsid proteinSARS-CoV-2

Identifiers

PMID38576796
PMCPMC10994262
OpenAlexW4393965951

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.