Evidence map›Paper›PMID 38576631›Full record

ReviewCureus2024

Micro-RNAs With Prognostic Significance in Gallbladder Cancer: A Systematic Review and Meta-Analysis.

Rahul Saxena, Sarath Krishnan M P, Christhunesa S Christudass, Anil Chauhan, Vivek S Malik, Amit Gupta, Sweety Gupta, Akhil Anthwal, Bela Goyal

Open access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Rahul SaxenaBiochemistry, All India Institute of Medical Sciences, Rishikesh, Rishikesh, IND.
Sarath Krishnan M PBiochemistry, All India Institute of Medical Sciences, Rishikesh, Rishikesh, IND.
Christhunesa S ChristudassNeurological Sciences, Christian Medical College Vellore, Vellore, IND.
Anil ChauhanTelemedicine, Postgraduate Institute of Medical Education and Research, Chandigarh, IND.
Vivek S MalikTelemedicine, Centre for Evidence Synthesis and Public Policy, All India Institute of Medical Sciences, Rishikesh, Rishikesh, IND.
Amit GuptaGeneral Surgery, All India Institute of Medical Sciences, Rishikesh, Rishikesh, IND.
Sweety GuptaRadiation Oncology, All India Institute of Medical Sciences, Rishikesh, Rishikesh, IND.
Akhil AnthwalBiochemistry, All India Institute of Medical Sciences, Rishikesh, Rishikesh, IND.
Bela GoyalBiochemistry, All India Institute of Medical Sciences, Rishikesh, Rishikesh, IND.
Post Graduate Institute of Medical Education and Research · INAll India Institute of Medical Sciences RishikeshChristian Medical College & Hospital · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gallbladder cancer (GBC) stands out as one of the most widespread malignancies impacting the biliary tract globally. Despite increasing interest, to the best of our knowledge, no meta-analysis has been undertaken to amalgamate the existing data concerning the prognostic significance of micro-RNAs (miRNAs) in GBC in comparison to studies on miRNAs in other cancers. Hence, this systematic review and meta-analysis aimed at determining the prognostic significance of miRNAs in GBC patients. Comprehensive literature searches were conducted across PubMed, Cochrane Library, Ovid, Scopus, and Science Direct databases. Studies that evaluated the association between miRNAs and overall survival in GBC patients were included. Random-effect meta-analysis was employed to pool hazard ratios (HRs) and their 95% confidence intervals (CIs) across studies. A total of 15 studies, encompassing 16 miRs, were included for our analysis. The pooled analysis revealed that a high expression of miR-204, miR-7-2-3p, miR-29c-3p, miR-125b, miR-20a, miR-139-5p, miR-141, miR-92b-3p, miR-335, and miR-372 was significantly associated with poor prognosis and increased risk (HR>1 and the upper bound of the 95% CI>1). Additionally, these miRNAs were associated with the overall survival (HR = 1.56, 95% CI = 0.91-2.20,

Indexed as

gallbladder cancer (gbc)hazard ratiomicrornas (mirnas)overall survival (os)prognostic significance

Identifiers

PMID38576631
PMCPMC10990876
OpenAlexW4392375972

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.