Evidence map›Paper›PMID 38576487›Full record

ArticleFrontiers in pharmacology2024

Interfering with reconsolidation by rimonabant results in blockade of heroin-associated memory.

Jiang Lin, Yilin Peng, Jinlong Zhang, Junzhe Cheng, Qianqian Chen, Binbin Wang, Yuhang Liu, Shuliang Niu, Jie Yan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Jiang Lin *Department of Forensic Science, School of Basic Medical Science, Central South University, Changsha, Hunan, China.
Yilin Peng *Department of Forensic Science, School of Basic Medical Science, Central South University, Changsha, Hunan, China.
Jinlong ZhangDepartment of Forensic Science, School of Basic Medical Science, Central South University, Changsha, Hunan, China.
Junzhe ChengDepartment of Forensic Science, School of Basic Medical Science, Central South University, Changsha, Hunan, China.
Qianqian ChenDepartment of Forensic Science, School of Basic Medical Science, Central South University, Changsha, Hunan, China.
Binbin WangDepartment of Forensic Science, School of Basic Medical Science, Central South University, Changsha, Hunan, China.
Yuhang LiuDepartment of Forensic Science, School of Basic Medical Science, Central South University, Changsha, Hunan, China.
Shuliang NiuDepartment of Forensic Science, School of Basic Medical Science, Central South University, Changsha, Hunan, China.
Jie YanDepartment of Forensic Science, School of Basic Medical Science, Central South University, Changsha, Hunan, China.
Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Drug-associated pathological memory remains a critical factor contributing to the persistence of substance use disorder. Pharmacological amnestic manipulation to interfere with drug memory reconsolidation has shown promise for the prevention of relapse. In a rat heroin self-administration model, we examined the impact of rimonabant, a selective cannabinoid receptor indirect agonist, on the reconsolidation process of heroin-associated memory. The study showed that immediately administering rimonabant after conditioned stimuli (CS) exposure reduced the cue- and herion + cue-induced heroin-seeking behavior. The inhibitory effects lasted for a minimum of 28 days. The effect of Rimonabant on reduced drug-seeking was not shown when treated without CS exposure or 6 hours after CS exposure. These results demonstrate a disruptive role of rimonabant on the reconsolidation of heroin-associated memory and the therapeutic potential in relapse control concerning substance use disorder.

Indexed as

heroin-associated memoryheroin-seekingreconsolidationrelapserimonabant

Identifiers

PMID38576487
PMCPMC10991728
OpenAlexW4393054479

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.