Evidence map›Paper›PMID 38576249›Full record

ArticleAnnals of dermatology2024

Risk of Developing Hypertension in Atopic Dermatitis Patients Receiving Long-term and Low-dose Cyclosporine: A Nationwide Population-based Cohort Study.

Yu Ri Woo, Arum Choi, Seo Won Song, Suyeun Kim, Sang Wook Son, Sang Hyun Cho, Sukil Kim, Jung Eun Kim

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of dermatology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Yu Ri WooDepartment of Dermatology, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.ORCID https://orcid.org/0000-0003-2903-9534
Arum ChoiDepartment of Preventive Medicine and Public Health, College of Medicine, The Catholic University of Korea, Seoul, Korea.ORCID https://orcid.org/0000-0002-5532-0103
Seo Won SongDepartment of Dermatology, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.ORCID https://orcid.org/0000-0003-3315-0761
Suyeun KimDepartment of Dermatology, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.ORCID https://orcid.org/0000-0002-1795-9977
Sang Wook SonDepartment of Dermatology, Korea University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-3332-7056
Sang Hyun ChoDepartment of Dermatology, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.ORCID https://orcid.org/0000-0001-8289-1190
Sukil KimDepartment of Preventive Medicine and Public Health, College of Medicine, The Catholic University of Korea, Seoul, Korea. sikimmd@catholic.ac.kr.ORCID https://orcid.org/0000-0001-9730-9845
Jung Eun KimDepartment of Dermatology, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea. mdkjeun@naver.com.ORCID https://orcid.org/0000-0003-1670-0995
The Catholic University of Korea Incheon St. Mary's Hospital · KRSt. Mary's Hospital · USCatholic University of Korea · KRKorea University · KR

Funding

Korean Atopic Department AssociationKorean Health Industry Development Institute HI19C1298Memorandum of UnderstandingNational Health Insurance Service NHIS-2021-1-877
6 · The paper itself

Abstract

backgroundCyclosporine (CS) is a first-line immunosuppressive agent used to manage moderate to severe atopic dermatitis (AD). To date, the risk of developing hypertension associated with the long-term use of low-dose CS in AD patients is understudied.

objectiveTo determine the cumulative dose-dependent effect of CS on the risk of developing hypertension in patients with AD.

methodsA nationwide population-based retrospective cohort with 1,844,009 AD patients was built from the Korean National Health Insurance System database from 2005 to 2009. A Cox proportional-hazard regression analysis was performed according to patients' CS treatment history adjusted for potential confounders.

resultsCurrent use of CS was associated with an increased risk of developing hypertension (adjusted hazard ratio, 4.442; 95% confidence interval, 3.761-5.247). Among the current CS users, a higher cumulative dose of CS (≥39,725 mg) or longer cumulative use of CS (≥182 days), was significantly associated with an increased risk of developing hypertension.

conclusionThe incidence of CS-associated hypertension is very low when using low-dose treatment regimens for AD. However, the current use or a high cumulative dose of CS for treating patients with AD increases the risk of developing hypertension. Precaution is needed when prescribing CS for long-term treatment of AD.

Indexed as

Atopic dermatitisCyclosporineDose-response relationship, drugHypertensionRisk

Identifiers

PMID38576249
PMCPMC10995617
OpenAlexW4392833601

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.