Evidence map›Paper›PMID 38576180›Full record

ArticleAmerican journal of epidemiology2024

Multiple prenatal exposures and acute-care clinical encounters for asthma among children born to mothers living near a Superfund site.

Roxana Khalili, Jesselle M Legaspi, M Patricia Fabian, Jonathan I Levy, Susan A Korrick, Verónica M Vieira

Open access · bronzeAbstract read
In one paragraph

Article in American journal of epidemiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Jesselle M Legaspi
M Patricia FabianORCID 0000-0002-1658-3349
Verónica M VieiraORCID 0000-0001-7153-4606
Boston University · USUniversity of California, Irvine · USBrigham and Women's Hospital · USUniversity of Southern California · US

Funding

Training CoreP42ES007381 · NIEHS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MONTI, STEFANO · 1995 to 2019
$46.1M
Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI JAIME ELIZABETH HART · 1985 to 2026
$44.6M
VANADIUM AND HUMAN HEALTHP42ES005947 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI KELSEY, KARL TIMOTHY · 1992 to 2006
$19.6M
Metal and Organochlorines Exposure: Impact on Adolescent Behavior and CognitionR01ES014864 · NIEHS · BRIGHAM AND WOMEN'S HOSPITAL · PI KORRICK, SUSAN A · 2006 to 2010
$3.3M
Asthma Simulation Tool for Housing, Medication and Social Adversity (ASTHMA)R01ES027816 · NIEHS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI FABIAN, MARIA PATRICIA · 2017 to 2021
$2.4M
Spatial and Temporal Modeling of PM2.5 and Infant MorbidityR01ES019897 · NIEHS · UNIVERSITY OF CALIFORNIA-IRVINE · PI VIEIRA, VERONICA M · 2011 to 2015
$1.8M
NIEHS NIH HHS P30 ES000002NIEHS NIH HHS P42 ES005947NIEHS NIH HHS P42 ES007381NIEHS NIH HHS R01 ES014864NIEHS NIH HHS R01 ES019897NIEHS NIH HHS R01 ES027816
6 · The paper itself

Abstract

Prenatal exposures are associated with childhood asthma, and risk may increase with simultaneous exposures. Pregnant women living in lower-income communities tend to have elevated exposures to a range of potential asthma risk factors, which may interact in complex ways. We examined the association between prenatal exposures and the risk of childhood acute-care clinical encounters for asthma (hospitalizations, emergency department visits, observational stays) using conditional logistic regression with a multivariable smoothing term to model the interaction between continuous variables, adjusted for maternal characteristics and stratified by sex. All births near the New Bedford Harbor (NBH) Superfund site (2000-2006) in New Bedford, Massachusetts, were followed through 2011 using the Massachusetts Pregnancy to Early Life Longitudinal (PELL) Data System to identify children aged 5-11 years with acute-care clinical asthma encounters (265 cases among 7787 children with follow-up). Hazard ratios (HRs) were higher for children living closer to the NBH site with higher umbilical cord blood lead levels than in children living further away from the NBH site with lower lead levels (P <.001). HRs were higher for girls (HR = 4.17; 95% CI, 3.60-4.82) than for boys (HR = 1.72; 95% CI, 1.46-2.02). Our results suggest that prenatal lead exposure in combination with residential proximity to the NBH Superfund site is associated with childhood asthma acute-care clinical encounters. This article is part of a Special Collection on Environmental Epidemiology.

Indexed as

AsthmaPrenatal Exposure Delayed EffectsAdultChildChild, PreschoolEmergency Service, HospitalEnvironmental ExposureFemaleFetal BloodHospitalizationHumansLeadLogistic ModelsLongitudinal StudiesMaleMassachusettsLeadbirth cohortchildhood asthmageneralized additive modelsleadmixturesmultiple exposuresorganochlorinesprenatal exposures

Identifiers

PMID38576180
PMCPMC12096289
OpenAlexW4393987480

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.