Evidence map›Paper›PMID 38576169›Full record

Trial reportJournal of the International Society of Sports Nutrition2024

Oral post-exercise garlic extract supplementation enhances glycogen replenishment but does not up-regulate mitochondria biogenesis mRNA expression in human-exercised skeletal muscle.

I-Shiung Cheng, Jung-Piao Tsao, Jeffrey R Bernard, Tsen-Wei Tsai, Chia-Chen Chang, Su-Fen Liao

Open access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of the International Society of Sports Nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

I-Shiung ChengNational Taichung University of Education, Department of Physical Education, Taichung City, Taiwan.ORCID 0000-0002-0532-0367
Jung-Piao TsaoDepartment of Sports Medicine, China Medical University, Taichung City, Taiwan.
Jeffrey R BernardDepartment of Kinesiology and Public Health Promotion,California State University, Stanislaus, Turlock, USA.
Tsen-Wei TsaiDepartment of Nursing, Taichung, China Medical University Hospital, Taiwan.
Chia-Chen ChangCollege of HuilanNational Dong Hwa University, Physical Education Center, Hualien, Taiwan.
Su-Fen LiaoDepartment of Physical Medicine and Rehabilitation, Changhua Christian Hospital, Changhua, Taiwan.
China Medical University · TWCalifornia State University, Stanislaus · USNational Chung Hsing University · TWNational Dong Hwa University · TWNational Taichung University of Education · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeGarlic extract (GA) is purported to enhance antioxidant and anti-inflammatory activity and glucose regulation in humans. The present study investigated the effects of post-exercise GA supplementation on GLUT4 expression, glycogen replenishment, and the transcript factors involved with mitochondrial biosynthesis in exercised human skeletal muscle.

methodsThe single-blinded crossover counterbalanced study was completed by 12 participants. Participants were randomly divided into either GA (2000 mg of GA) or placebo trials immediately after completing a single bout of cycling exercise at 75% Maximal oxygen uptake (VO

resultsSkeletal muscle glycogen replenishment was significantly elevated during the 3-h recovery period for GA concurrent with no difference in GLUT4 protein expression between the garlic and placebo trials. PGC1-α gene expression was up-regulated for both GA and placebo after exercise (

conclusionAcute post-exercise garlic supplementation may improve the replenishment of muscle glycogen, but this appears to be unrelated to the gene expression for glucose uptake and mitochondrial biosynthesis in exercised human skeletal muscle.

Indexed as

GarlicGlycogenAntioxidantsBlood GlucoseDietary SupplementsGlucoseGlucose Transporter Type 4HumansMitochondriaMuscle, SkeletalRNA, MessengerAntioxidantsBlood GlucoseGlucoseGlucose Transporter Type 4GlycogenRNA, MessengerErgogenic propertyexercisemuscle adaptationphytochemicals

Identifiers

PMID38576169
PMCPMC11000618
OpenAlexW4393983952

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.