Evidence map›Paper›PMID 38576117›Full record

ReviewWiley interdisciplinary reviews. RNA

RNA-binding proteins in pain.

Patrick R Smith, Zachary T Campbell

Open access · greenAbstract readReview
In one paragraph

Review in Wiley interdisciplinary reviews. RNA. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Patrick R SmithDepartment of Anaesthesiology, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0001-8713-5386
Zachary T CampbellDepartment of Anaesthesiology, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0002-3768-6996
University of Wisconsin–Madison · US

Funding

Profiling Translation in Nociceptor PlasticityR01NS114018 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI Zachary Campbell · 2020 to 2026
$3.2M
NINDS NIH HHS R01 NS114018NINDS NIH HHS R01NS114018
6 · The paper itself

Abstract

RNAs are meticulously controlled by proteins. Through direct and indirect associations, every facet in the brief life of an mRNA is subject to regulation. RNA-binding proteins (RBPs) permeate biology. Here, we focus on their roles in pain. Chronic pain is among the largest challenges facing medicine and requires new strategies. Mounting pharmacologic and genetic evidence obtained in pre-clinical models suggests fundamental roles for a broad array of RBPs. We describe their diverse roles that span RNA modification, splicing, stability, translation, and decay. Finally, we highlight opportunities to expand our understanding of regulatory interactions that contribute to pain signaling. This article is categorized under: RNA Interactions with Proteins and Other Molecules > Protein-RNA Interactions: Functional Implications Translation > Regulation RNA in Disease and Development > RNA in Disease.

Indexed as

RNA-Binding ProteinsRNA SplicingHumansPainRNA, MessengerRNA-Binding ProteinsRNA, MessengerpainRBPRNA stabilitysplicingtranslational control

Identifiers

PMID38576117
PMCPMC11003723
OpenAlexW4393983990

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.