Evidence map›Paper›PMID 38576034›Full record

SynthesisMolecular autism2024

Systematic review and meta-analysis: multimodal functional and anatomical neural alterations in autism spectrum disorder.

Zixuan Guo, Xinyue Tang, Shu Xiao, Hong Yan, Shilin Sun, Zibin Yang, Li Huang, Zhuoming Chen, Ying Wang

Open access · goldAbstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Molecular autism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 10 pooled it
24.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 10 syntheses or guidelines pooled it, 71 citations in OpenAlex.

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  7. Valproate Exposure as anCNS & neurological disorders drug targets · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Zixuan Guo *Medical Imaging Center, The First Affiliated Hospital of Jinan University, Guangzhou, China.
Xinyue Tang *Medical Imaging Center, The First Affiliated Hospital of Jinan University, Guangzhou, China.
Shu XiaoMedical Imaging Center, The First Affiliated Hospital of Jinan University, Guangzhou, China.
Hong YanMedical Imaging Center, The First Affiliated Hospital of Jinan University, Guangzhou, China.
Shilin SunMedical Imaging Center, The First Affiliated Hospital of Jinan University, Guangzhou, China.
Zibin YangMedical Imaging Center, The First Affiliated Hospital of Jinan University, Guangzhou, China.
Li HuangMedical Imaging Center, The First Affiliated Hospital of Jinan University, Guangzhou, China.
Zhuoming ChenDepartment of Rehabilitation Medicine, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China.
Ying WangMedical Imaging Center, The First Affiliated Hospital of Jinan University, Guangzhou, China. johneil@vip.sina.com.
First Affiliated Hospital of Jinan University · CN

Funding

National Natural Science Foundation of China 81671670
6 · The paper itself

Abstract

backgroundThis meta-analysis aimed to explore the most robust findings across numerous existing resting-state functional imaging and voxel-based morphometry (VBM) studies on the functional and structural brain alterations in individuals with autism spectrum disorder (ASD).

methodsA whole-brain voxel-wise meta-analysis was conducted to compare the differences in the intrinsic functional activity and gray matter volume (GMV) between individuals with ASD and typically developing individuals (TDs) using Seed-based d Mapping software.

resultsA total of 23 functional imaging studies (786 ASD, 710 TDs) and 52 VBM studies (1728 ASD, 1747 TDs) were included. Compared with TDs, individuals with ASD displayed resting-state functional decreases in the left insula (extending to left superior temporal gyrus [STG]), bilateral anterior cingulate cortex/medial prefrontal cortex (ACC/mPFC), left angular gyrus and right inferior temporal gyrus, as well as increases in the right supplementary motor area and precuneus. For VBM meta-analysis, individuals with ASD displayed decreased GMV in the ACC/mPFC and left cerebellum, and increased GMV in the left middle temporal gyrus (extending to the left insula and STG), bilateral olfactory cortex, and right precentral gyrus. Further, individuals with ASD displayed decreased resting-state functional activity and increased GMV in the left insula after overlapping the functional and structural differences.

conclusionsThe present multimodal meta-analysis demonstrated that ASD exhibited similar alterations in both function and structure of the insula and ACC/mPFC, and functional or structural alterations in the default mode network (DMN), primary motor and sensory regions. These findings contribute to further understanding of the pathophysiology of ASD.

Indexed as

Autism Spectrum DisorderBrainCerebral CortexGray MatterGyrus CinguliHumansMagnetic Resonance ImagingAutism spectrum disorderGray matter volumeMeta-analysisResting-state functional imagingVoxel-based morphometry

Identifiers

PMID38576034
PMCPMC10996269
OpenAlexW4393950167

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.