Evidence map›Paper›PMID 38575923›Full record

ArticleJournal of nanobiotechnology2024

Chemically modified microRNA delivery via DNA tetrahedral frameworks for dental pulp regeneration.

Xiaoling Wei, Huaxing Xu, Mengqi Zhou, Qiangqiang Zhou, Mingqiang Li, Yuehua Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

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  12. Research progress of dental pulp regeneration treatment.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Xiaoling Wei *Shanghai Stomatological Hospital and School of Stomatology, Fudan University, Shanghai, 200001, China.
Huaxing Xu *Shanghai Stomatological Hospital and School of Stomatology, Fudan University, Shanghai, 200001, China.
Mengqi ZhouShanghai Stomatological Hospital and School of Stomatology, Fudan University, Shanghai, 200001, China.
Qiangqiang ZhouShanghai Stomatological Hospital and School of Stomatology, Fudan University, Shanghai, 200001, China.
Mingqiang LiSchool of Chemistry and Chemical Engineering, New Cornerstone Science Laboratory, Frontiers Science Center for Transformative Molecules, National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai, 200240, China. limingqiang@sjtu.edu.cn.
Yuehua LiuShanghai Stomatological Hospital and School of Stomatology, Fudan University, Shanghai, 200001, China. liuyuehua@fudan.edu.cn.
Fudan University · CNShanghai Jiao Tong University · CN

Funding

National Natural Science Foundation 82071153National Natural Science Foundation 82271007Shanghai Stomatological Hospital Shanghai Stomatological Hospital Institutional Project SSH-2022-02
6 · The paper itself

Abstract

Dental pulp regeneration is a promising strategy for addressing tooth disorders. Incorporating this strategy involves the fundamental challenge of establishing functional vascular networks using dental pulp stem cells (DPSCs) to support tissue regeneration. Current therapeutic approaches lack efficient and stable methods for activating DPSCs. In the study, we used a chemically modified microRNA (miRNA)-loaded tetrahedral-framework nucleic acid nanostructure to promote DPSC-mediated angiogenesis and dental pulp regeneration. Incorporating chemically modified miR-126-3p into tetrahedral DNA nanostructures (miR@TDNs) represents a notable advancement in the stability and efficacy of miRNA delivery into DPSCs. These nanostructures enhanced DPSC proliferation, migration, and upregulated angiogenesis-related genes, enhancing their paracrine signaling effects on endothelial cells. This enhanced effect was substantiated by improvements in endothelial cell tube formation, migration, and gene expression. Moreover, in vivo investigations employing matrigel plug assays and ectopic dental pulp transplantation confirmed the potential of miR@TDNs in promoting angiogenesis and facilitating dental pulp regeneration. Our findings demonstrated the potential of chemically modified miRNA-loaded nucleic acid nanostructures in enhancing DPSC-mediated angiogenesis and supporting dental pulp regeneration. These results highlighted the promising role of chemically modified nucleic acid-based delivery systems as therapeutic agents in regenerative dentistry and tissue engineering.

Indexed as

MicroRNAsCell DifferentiationCell ProliferationDental PulpDNAEndothelial CellsRegenerationStem CellsDNAMicroRNAsAngiogenesisDental pulp regenerationDental pulp stem cellsNucleic acid modificationsTetrahedral-framework nucleic acid nanostructure

Identifiers

PMID38575923
PMCPMC11318316
OpenAlexW4393947864

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.