ArticleBMC oral health2024
Comparative analysis of microbial composition and functional characteristics in dental plaque and saliva of oral cancer patients.
Article in BMC oral health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 12 citations in OpenAlex.
- Microbiota and head and neck cancers: Mechanistic insights and translational potential.Virulence · 2026Review
- Comparison of microbiome profiles across sample types in patients with peri-implantitis using 16S rRNA sequencing.Journal of periodontal & implant science · 2026Article
- Host-microbiome-immune disequilibrium in oral disease: mechanisms, dysbiosis, and precision therapeutics.Frontiers in immunology · 2026Review
- The role ofFrontiers in oral health · 2026Review
- Bacteriome-based oral dysbiosis index in patients with oral squamous cell carcinoma.Journal of oral microbiology · 2026Article
- Effect of gamma radiation on human enamel chemical and physical properties.BMC oral health · 2025Article
- Oral Microbiome Analysis and Caries Risk Classification Using the Caries Management by Risk Assessment System in Pre-Orthodontic Patients.Journal of clinical medicine · 2025Article
- Dynamic changes of dental plaque and saliva microbiota in OSCC progression.Clinical oral investigations · 2025Article
- Analysis of the current situation and risk factors of nosocomial infections in oral cancer patients after surgery.World journal of surgical oncology · 2025Article
- Salivary microbiome in peritoneal dialysis patients with and without sarcopenia: A pilot study.PloS one · 2025Article
- Development and Evaluation of the Biological Activities of a Plain Mucoadhesive Hydrogel as a Potential Vehicle for Oral Mucosal Drug Delivery.Gels (Basel, Switzerland) · 2024Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe oral cavity is home to various ecological niches, each with its own unique microbial composition. Understanding the microbial communities and gene composition in different ecological niches within the oral cavity of oral cancer (OC) patients is crucial for determining how these microbial populations contribute to disease progression.
methodsIn this study, saliva and dental plaque samples were collected from patients with OC. Metagenomic sequencing was employed to analyze the microbial community classification and functional composition of the different sample groups.
resultsThe results of the study revealed significant differences in both the function and classification of microbial communities between saliva and dental plaque samples. The diversity of microbial species in saliva was found to be higher compared to that in plaque samples. Notably, Actinobacteria were enriched in the dental plaque of OC patients. Furthermore, the study identified several inter-group differential marker species, including Prevotella intermedia, Haemophilus parahaemolyticus, Actinomyces radius, Corynebacterium matruchitii, and Veillonella atypica. Additionally, 1,353 differential genes were annotated into 23 functional pathways. Interestingly, a significant correlation was observed between differentially labeled species and Herpes simplex virus 1 (HSV-1) infection, which may be related to the occurrence and development of cancer.
conclusionsSignificant differences in the microbial and genetic composition of saliva and dental plaque samples were observed in OC patients. Furthermore, pathogenic bacteria associated with oral diseases were predominantly enriched in saliva. The identification of inter-group differential biomarkers and pathways provide insights into the relationship between oral microbiota and the occurrence and development of OC.
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