Evidence map›Paper›PMID 38575865›Full record

ArticleBMC microbiology2024

Ultraviolet C inactivation of Coxiella burnetii for production of a structurally preserved whole cell vaccine antigen.

Katja Mertens-Scholz, Amira A Moawad, Elisabeth M Liebler-Tenorio, Andrea Helming, Jennifer Andrack, Peter Miethe, Heinrich Neubauer, Mathias W Pletz, Ina-Gabriele Richter

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Katja Mertens-Scholz *Friedrich-Loeffler-Institut, Institute of Bacterial Infections and Zoonoses, Jena, Germany. katja.mertens-scholz@fli.de.
Amira A Moawad *Friedrich-Loeffler-Institut, Institute of Bacterial Infections and Zoonoses, Jena, Germany.
Elisabeth M Liebler-TenorioFriedrich-Loeffler-Institut, Institute of Molecular Pathogenesis, Jena, Germany.
Andrea HelmingDepartment of In Vitro Diagnostics Development, Research Centre of Medical Technology and Biotechnology, Erfurt, Germany.
Jennifer AndrackFriedrich-Loeffler-Institut, Institute of Bacterial Infections and Zoonoses, Jena, Germany.
Peter MietheResearch Centre of Medical Technology and Biotechnology, Bad Langensalza, Germany.
Heinrich NeubauerFriedrich-Loeffler-Institut, Institute of Bacterial Infections and Zoonoses, Jena, Germany.
Mathias W PletzInstitute for Infectious Diseases and Infection Control and Center for Sepsis Care and Control (CSCC), Jena University Hospital, Jena, Germany.
Ina-Gabriele RichterResearch Centre of Medical Technology and Biotechnology, Bad Langensalza, Germany.
Friedrich-Loeffler-Institut · DEResearch Centre of Medical Technology and Biotechnology · DEJena University Hospital · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Q fever, a worldwide-occurring zoonotic disease, can cause economic losses for public and veterinary health systems. Vaccines are not yet available worldwide and currently under development. In this regard, it is important to produce a whole cell antigen, with preserved structural and antigenic properties and free of chemical modifications. Thus, inactivation of Coxiella burnetii with ultraviolet light C (UVC) was evaluated. C. burnetii Nine Mile phase I (NMI) and phase II (NMII) were exposed to decreasing intensities in a time-dependent manner and viability was tested by rescue cultivation in axenic medium or cell culture. Effects on the cell structure were visualized by transmission electron microscopy and antigenicity of UVC-treated NMI was studied by immunization of rabbits. NMI and NMII were inactivated at UVC intensities of 250 µW/cm

Indexed as

Coxiella burnetiiQ FeverVaccinesAnimalsRabbitsVaccinesAntibody responseCoxiella burnetiiELISAImmunizationSurvival rateTransmission electron microscopyUVC irradiation

Identifiers

PMID38575865
PMCPMC10993581
OpenAlexW4393941342

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.