Evidence map›Paper›PMID 38575831›Full record

Observational studyJournal of neurovirology2024

Differences in neuroinflammation in people who started antiretroviral treatment during primary versus chronic HIV infection: an 18kDa Translocator protein (TSPO) positron emission tomography (PET) study.

Jasmini Alagaratnam, John P Thornhill, Zhen Fan, Jaime H Vera, Jonathan Underwood, Rebecca Hall, Graham Searle, David Owen, Paul Edison, Sarah Fidler and 1 more

Open access · hybridAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of neurovirology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 95% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 1 country.

Jasmini AlagaratnamDepartment of Sexual Health & HIV, Chelsea & Westminster Hospital NHS Foundation Trust, London, UK. j.alagaratnam@nhs.net.
John P ThornhillBlizard Institute, Barts & the London School of Medicine & Dentistry, Queen Mary University of London, London, UK.
Zhen FanInvicro, A Konica Minolta Company, London, UK.
Jaime H VeraDepartment of Global Health and Infection, Brighton and Sussex Medical School, London, UK.
Jonathan UnderwoodDivision of Infection and Immunity, School of Medicine, Cardiff University, UHW Main Building, Heath Park, Cardiff, CF14 4XN, UK.
Rebecca HallDepartment of Infectious Disease, Faculty of Medicine, Imperial College London, London, UK.
Graham SearleInvicro, A Konica Minolta Company, London, UK.
David OwenDepartment of Brain Sciences, Imperial College London, London, UK.
Paul EdisonDepartment of Brain Sciences, Imperial College London, London, UK.
Sarah FidlerDepartment of Infectious Disease, Faculty of Medicine, Imperial College London, London, UK.
Alan WinstonDepartment of Infectious Disease, Faculty of Medicine, Imperial College London, London, UK.
Imperial College London · GBInvicro (United Kingdom) · GBBrighton and Sussex Medical School · GBCardiff University · GBChelsea and Westminster Hospital NHS Foundation Trust · GBImperial College Healthcare NHS Trust · GBQueen Mary University of London · GBSt. Mary's Hospital · GB

Funding

Medical Research Council MR/T023791/1NIHR Imperial Biomedical Research Centre P57282
6 · The paper itself

Abstract

Persistent inflammation is described in people with HIV (PWH) on antiretroviral treatment (ART). Early ART initiation is associated with reduced inflammation. We aimed to evaluate neuroinflammation, using translocator protein (TSPO) [

Indexed as

HIV InfectionsNeuroinflammatory DiseasesReceptors, GABAAdultAnti-HIV AgentsAnti-Retroviral AgentsBrainCarbon RadioisotopesChronic DiseaseCross-Sectional StudiesFemaleGray MatterHumansMaleMiddle AgedPositron-Emission TomographyAnti-HIV AgentsAnti-Retroviral AgentsCarbon RadioisotopesPyridinesRadiopharmaceuticalsReceptors, GABATSPO protein, humanHIVNeuroinflammationPBR28Primary HIVTSPO

Identifiers

PMID38575831
PMCPMC11371857
OpenAlexW4393951259

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.