Evidence map›Paper›PMID 38575590›Full record

ArticleNature communications2024

Distinct local and global functions of mouse Aβ low-threshold mechanoreceptors in mechanical nociception.

Mayank Gautam, Akihiro Yamada, Ayaka I Yamada, Qinxue Wu, Kim Kridsada, Jennifer Ling, Huasheng Yu, Peter Dong, Minghong Ma, Jianguo Gu and 1 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 21 citations in OpenAlex.

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  7. Skin innervation and itsFrontiers in cellular neuroscience · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Mayank GautamDepartment of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.ORCID http://orcid.org/0000-0002-7257-5837
Akihiro Yamada *Department of Anesthesiology and Perioperative Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Ayaka I Yamada *Department of Anesthesiology and Perioperative Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Qinxue WuDepartment of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Kim KridsadaDepartment of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Jennifer LingDepartment of Anesthesiology and Perioperative Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Huasheng YuDepartment of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Peter DongDepartment of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Minghong MaDepartment of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.ORCID http://orcid.org/0000-0002-5027-9623
Jianguo GuDepartment of Anesthesiology and Perioperative Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294, USA. jianguogu@uabmc.edu.ORCID http://orcid.org/0000-0002-8404-9850
Wenqin LuoDepartment of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. luow@pennmedicine.upenn.edu.ORCID http://orcid.org/0000-0002-2486-807X
University of Pennsylvania · USUniversity of Alabama at Birmingham · US

Funding

Mechanisms of Nociception in the Trigeminal SystemR01DE018661 · NIDCR · UNIVERSITY OF FLORIDA · PI JIANGUO GU · 2008 to 2026
$6.9M
Cellular and Ion Channel Mechanisms Underlying the Sense of Light Touch in MammalsR01DE023090 · NIDCR · UNIVERSITY OF CINCINNATI · PI JIANGUO GU · 2013 to 2026
$6.1M
Molecular mechanisms in controlling development of touch-sensing neuronsR01NS083702 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI LUO, WENQIN · 2013 to 2022
$4.1M
Ion channels and their functions at the node of Ranvier of mammalian somatosensory afferent fibersR01NS109059 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GU, JIANGUO · 2019 to 2023
$2.2M
NIDCR NIH HHS R01 DE018661NIDCR NIH HHS R01 DE023090NINDS NIH HHS R01 NS083702NINDS NIH HHS R01 NS109059
6 · The paper itself

Abstract

The roles of Aβ low-threshold mechanoreceptors (LTMRs) in transmitting mechanical hyperalgesia and in alleviating chronic pain have been of great interest but remain contentious. Here we utilized intersectional genetic tools, optogenetics, and high-speed imaging to specifically examine functions of Split

Indexed as

Chronic PainHyperalgesiaAnimalsInflammationMechanoreceptorsMiceNociception

Identifiers

PMID38575590
PMCPMC10995180
OpenAlexW4393938784

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.