Evidence map›Paper›PMID 38575510›Full record

ArticleJournal of gastric cancer2024

A Modified eCura System to Stratify the Risk of Lymph Node Metastasis in Undifferentiated-Type Early Gastric Cancer After Endoscopic Resection.

Hyo-Joon Yang, Hyuk Lee, Tae Jun Kim, Da Hyun Jung, Kee Don Choi, Ji Yong Ahn, Wan Sik Lee, Seong Woo Jeon, Jie-Hyun Kim, Gwang Ha Kim and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of gastric cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 11 institutions in 1 country.

Hyo-Joon YangDivision of Gastroenterology, Department of Internal Medicine and Gastrointestinal Cancer Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-0265-672X
Hyuk LeeDepartment of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0003-4271-7205
Tae Jun KimDepartment of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0001-8101-9034
Da Hyun JungDepartment of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0001-6668-3113
Kee Don ChoiDivision of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-2517-4109
Ji Yong AhnDivision of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-0030-3744
Wan Sik LeeDepartment of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.ORCID https://orcid.org/0000-0002-8021-6228
Seong Woo JeonDepartment of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Korea.ORCID https://orcid.org/0000-0002-9539-9389
Jie-Hyun KimDepartment of Internal Medicine, Institute of Gastroenterology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-9198-3326
Gwang Ha KimDepartment of Internal Medicine, Pusan National University School of Medicine, Busan, Korea.ORCID https://orcid.org/0000-0001-9721-5734
Jae Myung ParkDepartment of Internal Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea.ORCID https://orcid.org/0000-0002-1534-7467
Sang Gyun KimDivision of Gastroenterology, Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0003-1799-9028
Woon Geon ShinDepartment of Internal Medicine, Institute for Liver and Digestive Diseases, Hallym University College of Medicine, Chuncheon, Korea.ORCID https://orcid.org/0000-0002-9851-5576
Young-Il KimCenter for Gastric Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Korea.ORCID https://orcid.org/0000-0002-2614-3419
Il Ju ChoiCenter for Gastric Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Korea. cij1224@ncc.re.kr.ORCID https://orcid.org/0000-0002-8339-9824
National Cancer Center · KRSamsung Medical Center · KRUlsan College · KRYonsei University · KRChonnam National University · KRHallym University · KRKangbuk Samsung Hospital · KRKyungpook National University · KRPusan National University · KRSeoul National University Hospital · KRThe Catholic University of Korea Seoul St. Mary's Hospital · KR

Funding

Ministry of Health and Welfare HC20C0123
6 · The paper itself

Abstract

purposeThe original eCura system was designed to stratify the risk of lymph node metastasis (LNM) after endoscopic resection (ER) in patients with early gastric cancer (EGC). We assessed the effectiveness of a modified eCura system for reflecting the characteristics of undifferentiated-type (UD)-EGC. MATERIALS AND

methodsSix hundred thirty-four patients who underwent non-curative ER for UD-EGC and received either additional surgery (radical surgery group; n=270) or no further treatment (no additional treatment group; n=364) from 18 institutions between 2005 and 2015 were retrospectively included in this study. The eCuraU system assigned 1 point each for tumors >20 mm in size, ulceration, positive vertical margin, and submucosal invasion <500 µm; 2 points for submucosal invasion ≥500 µm; and 3 points for lymphovascular invasion.

resultsLNM rates in the radical surgery group were 1.1%, 5.4%, and 13.3% for the low- (0-1 point), intermediate- (2-3 points), and high-risk (4-8 points), respectively (P-for-trend<0.001). The eCuraU system showed a significantly higher probability of identifying patients with LNM as high-risk than the eCura system (66.7% vs. 22.2%; McNemar P<0.001). In the no additional treatment group, overall survival (93.4%, 87.2%, and 67.6% at 5 years) and cancer-specific survival (99.6%, 98.9%, and 92.9% at 5 years) differed significantly among the low-, intermediate-, and high-risk categories, respectively (both P<0.001). In the high-risk category, surgery outperformed no treatment in terms of overall mortality (hazard ratio, 3.26; P=0.015).

conclusionsThe eCuraU system stratified the risk of LNM in patients with UD-EGC after ER. It is strongly recommended that high-risk patients undergo additional surgery.

Indexed as

Endoscopic mucosal resectionLymph node metastasisRisk assessmentStomach neoplasmsUndifferentiated-type histology

Identifiers

PMID38575510
PMCPMC10995829
OpenAlexW4391112190

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.