Evidence map›Paper›PMID 38575358›Full record

ArticleLife science alliance2024

Acetylation of Rec8 cohesin complexes regulates reductional chromosome segregation in meiosis.

Ziqiang Li, Yu Liu, Andrew W Jones, Yoshinori Watanabe

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life science alliance, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Ziqiang LiScience Center for Future Foods, Jiangnan University, Wuxi, China.ORCID 0009-0006-1696-6063
Yu LiuScience Center for Future Foods, Jiangnan University, Wuxi, China.
Andrew W JonesCell Cycle Laboratory, The Francis Crick Institute, London, UK.
Yoshinori WatanabeScience Center for Future Foods, Jiangnan University, Wuxi, China ywatanabe@jiangnan.edu.cn.ORCID 0000-0002-5488-4812
Jiangnan University · CNThe Francis Crick Institute · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

For establishing sister chromatid cohesion and proper chromosome segregation in mitosis in fission yeast, the acetyltransferase Eso1 plays a key role. Eso1 acetylates cohesin complexes, at two conserved lysine residues K105 and K106 of the cohesin subunit Psm3. Although Eso1 also contributes to reductional chromosome segregation in meiosis, the underlying molecular mechanisms have remained elusive. Here, we purified meiosis-specific Rec8 cohesin complexes localized at centromeres and identified a new acetylation at Psm3-K1013, which largely depends on the meiotic kinetochore factor meikin (Moa1). Our molecular genetic analyses indicate that Psm3-K1013 acetylation cooperates with canonical acetylation at Psm3-K105 and K106, and plays a crucial role in establishing reductional chromosome segregation in meiosis.

Indexed as

SchizosaccharomycesSchizosaccharomyces pombe ProteinsAcetylationCell Cycle ProteinsChromosome SegregationCohesinsMeiosisCell Cycle ProteinsCohesinsEso1 protein, S pombeMoa1 protein, S pombeSchizosaccharomyces pombe Proteins

Identifiers

PMID38575358
PMCPMC10994779
OpenAlexW4393952106

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.