Evidence map›Paper›PMID 38575223›Full record

ReviewImmunology and allergy clinics of North America2024

The Relationship Between Eosinophilic Esophagitis and Immunotherapy.

Bridget E Wilson, Maria A Sacta, Benjamin L Wright, Jonathan Spergel, Nicole Wolfset

Open access · greenAbstract readReview
In one paragraph

Review in Immunology and allergy clinics of North America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Comparison of processing approaches for single-cell analysis of esophageal biopsy samples.The journal of allergy and clinical immunology. Global · 2026
    Article
  2. Article
  3. Article
  4. OMIT detergent?Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Bridget E WilsonDivision of Allergy, Asthma and Clinical Immunology, Department of Medicine, Mayo Clinic Arizona, 13400 E. Shea Boulevard Scottsdale, AZ 85259, USA; Division of Allergy/Immunology, Phoenix Children's, 1919 E. Thomas Road, Phoenix, AZ 85054, USA. Electronic address: wilson.bridget@mayo.edu.
Maria A SactaDivision of Allergy and Immunology, Children's Hospital of Philadelphia, 3401 Civic Center Boulevard, Philadelphia, PA 19104, USA.
Benjamin L WrightDivision of Allergy, Asthma and Clinical Immunology, Department of Medicine, Mayo Clinic Arizona, 13400 E. Shea Boulevard Scottsdale, AZ 85259, USA; Division of Allergy/Immunology, Phoenix Children's, 1919 E. Thomas Road, Phoenix, AZ 85054, USA.
Jonathan SpergelDivision of Allergy and Immunology, Children's Hospital of Philadelphia, 3401 Civic Center Boulevard, Philadelphia, PA 19104, USA.
Nicole WolfsetDivision of Allergy and Immunology, Children's Hospital of Philadelphia, 3401 Civic Center Boulevard, Philadelphia, PA 19104, USA.
Children's Hospital of Philadelphia · USMayo Clinic in Arizona · USPhoenix Children's Hospital · US

Funding

TRAINING (CAREER DEVELOPMENT) COMPONENTU54AI117804 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI GLENN T FURUTA, Marc E. Rothenberg · 2014 to 2026
$18.5M
CLINICAL PHARMACOLOGY TRAINING PROGRAMT32GM008562 · NIGMS · THOMAS JEFFERSON UNIVERSITY · PI WALTER K KRAFT, Scott A. Waldman · 1995 to 2026
$10.2M
Mechanisms of adverse gastrointestinal events during oral immunotherapyK23AI158813 · NIAID · MAYO CLINIC ARIZONA · PI Benjamin L. Wright · 2022 to 2026
$949k
NIAID NIH HHS K23 AI158813NIAID NIH HHS U54 AI117804NIGMS NIH HHS T32 GM008562
6 · The paper itself

Abstract

Immunotherapy is a treatment approach based on the principle of incremental allergen exposure to achieve desensitization. Recently, oral immunotherapy has been introduced as a treatment of IgE-mediated food allergy. Some patients receiving oral immunotherapy for food allergy may develop eosinophilic esophagitis. Here, we summarize the literature examining this association, its treatment, and outcomes and discuss possible explanations for this clinical phenomenon. We further identify potential associations with aeroallergen sensitivity and other forms of immunotherapy including subcutaneous immunotherapy and sublingual immunotherapy. Finally, we discuss management of immunotherapy-induced eosinophilic esophagitis. Epicutaneous immunotherapy is highlighted as an area of therapeutic investigation.

Indexed as

Eosinophilic EsophagitisFood HypersensitivitySublingual ImmunotherapyAllergensDesensitization, ImmunologicHumansAllergensAdverse effectsAllergy shotsEosinophilEosinophilic gastrointestinal diseaseOral immunotherapy

Identifiers

PMID38575223
PMCPMC11008775
OpenAlexW4391825318

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.