Evidence map›Paper›PMID 38575180›Full record

Trial reportCanadian journal of surgery. Journal canadien de chirurgie

Prospective assessment of the impact of intraoperative diuretics in kidney transplant recipient surgery.

Max A Levine, Andrew Rasmussen, Daniel Lee, Claire Rim, Kaveh Farokhi, Patrick P Luke, Alp Sener

Registry-linked trialOpen access · diamondAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Canadian journal of surgery. Journal canadien de chirurgie. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07726134 (A Pilot Randomized, Surgeon-blinded, Trial of Intraoperative Furosemide Versus Mannitol Among Deceased Donor Kidney Transplant Recipients), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07726134 nanot yet recruitingnot on this map

A Pilot Randomized, Surgeon-blinded, Trial of Intraoperative Furosemide Versus Mannitol Among Deceased Donor Kidney Transplant Recipients

TypeinterventionalSponsorLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph'sRan2026 to 2028Enrolled160ConditionsDelayed Graft Function, Kidney TransplantationArmsFurosemide, Mannitol
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Max A LevineFrom the Departments of Surgery (Levine, Rasmussen, Luke, Sener) and Microbiology & Immunology (Sener), Schulich School of Medicine & Dentistry, Western University, London, Ont.; the Matthew Mailing Centre for Translational Transplant Studies, London, Ont. (Lee, Rim, Farokhi, Luke, Sener); the Multi-Organ Transplant Program, London Health Sciences Centre, University Hospital, London, Ont. (Levine, Rasmussen, Luke, Sener); and the Division of Urology, Department of Surgery, University of Alberta, Edmonton, Alta. (Levine, Rasmussen).
Andrew RasmussenFrom the Departments of Surgery (Levine, Rasmussen, Luke, Sener) and Microbiology & Immunology (Sener), Schulich School of Medicine & Dentistry, Western University, London, Ont.; the Matthew Mailing Centre for Translational Transplant Studies, London, Ont. (Lee, Rim, Farokhi, Luke, Sener); the Multi-Organ Transplant Program, London Health Sciences Centre, University Hospital, London, Ont. (Levine, Rasmussen, Luke, Sener); and the Division of Urology, Department of Surgery, University of Alberta, Edmonton, Alta. (Levine, Rasmussen).
Daniel LeeFrom the Departments of Surgery (Levine, Rasmussen, Luke, Sener) and Microbiology & Immunology (Sener), Schulich School of Medicine & Dentistry, Western University, London, Ont.; the Matthew Mailing Centre for Translational Transplant Studies, London, Ont. (Lee, Rim, Farokhi, Luke, Sener); the Multi-Organ Transplant Program, London Health Sciences Centre, University Hospital, London, Ont. (Levine, Rasmussen, Luke, Sener); and the Division of Urology, Department of Surgery, University of Alberta, Edmonton, Alta. (Levine, Rasmussen).
Claire RimFrom the Departments of Surgery (Levine, Rasmussen, Luke, Sener) and Microbiology & Immunology (Sener), Schulich School of Medicine & Dentistry, Western University, London, Ont.; the Matthew Mailing Centre for Translational Transplant Studies, London, Ont. (Lee, Rim, Farokhi, Luke, Sener); the Multi-Organ Transplant Program, London Health Sciences Centre, University Hospital, London, Ont. (Levine, Rasmussen, Luke, Sener); and the Division of Urology, Department of Surgery, University of Alberta, Edmonton, Alta. (Levine, Rasmussen).
Kaveh FarokhiFrom the Departments of Surgery (Levine, Rasmussen, Luke, Sener) and Microbiology & Immunology (Sener), Schulich School of Medicine & Dentistry, Western University, London, Ont.; the Matthew Mailing Centre for Translational Transplant Studies, London, Ont. (Lee, Rim, Farokhi, Luke, Sener); the Multi-Organ Transplant Program, London Health Sciences Centre, University Hospital, London, Ont. (Levine, Rasmussen, Luke, Sener); and the Division of Urology, Department of Surgery, University of Alberta, Edmonton, Alta. (Levine, Rasmussen).
Patrick P LukeFrom the Departments of Surgery (Levine, Rasmussen, Luke, Sener) and Microbiology & Immunology (Sener), Schulich School of Medicine & Dentistry, Western University, London, Ont.; the Matthew Mailing Centre for Translational Transplant Studies, London, Ont. (Lee, Rim, Farokhi, Luke, Sener); the Multi-Organ Transplant Program, London Health Sciences Centre, University Hospital, London, Ont. (Levine, Rasmussen, Luke, Sener); and the Division of Urology, Department of Surgery, University of Alberta, Edmonton, Alta. (Levine, Rasmussen).
Alp SenerFrom the Departments of Surgery (Levine, Rasmussen, Luke, Sener) and Microbiology & Immunology (Sener), Schulich School of Medicine & Dentistry, Western University, London, Ont.; the Matthew Mailing Centre for Translational Transplant Studies, London, Ont. (Lee, Rim, Farokhi, Luke, Sener); the Multi-Organ Transplant Program, London Health Sciences Centre, University Hospital, London, Ont. (Levine, Rasmussen, Luke, Sener); and the Division of Urology, Department of Surgery, University of Alberta, Edmonton, Alta. (Levine, Rasmussen) alp.sener@lhsc.on.ca.
Western University · CALondon Health Sciences Centre · CAUniversity of Alberta · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe use of intraoperative diuretics, such as furosemide or mannitol, during kidney transplantation has been suggested to reduce the rate of delayed graft function (DGF). The evidence base for this is sparse, however, and there is substantial variation in practice. We sought to evaluate whether the use of intraoperative diuretics during kidney transplantation translated into a reduction in DGF.

methodsWe conducted a cohort study evaluating the use of furosemide or mannitol given intraoperatively before kidney reperfusion compared with control (no diuretic). Adult patients receiving a kidney transplant for end-stage renal disease were allocated to receive furosemide, mannitol, or no diuretic. The primary outcome was DGF; secondary outcomes were graft function at 30 days and perioperative changes in potassium levels. Descriptive and comparative statistics were used where appropriate.

resultsA total of 162 patients who received a kidney transplant from a deceased donor (either donation after neurologic determination of death or donation after circulatory death) were included over a 2-year period, with no significant between-group differences. There was no significant difference in DGF rates between the furosemide, mannitol, and control groups. When the furosemide and mannitol groups were pooled (any diuretic use) and compared with the control group, however, there was a significant improvement in the odds that patients would be free of DGF (odds ratio 2.10, 95% confidence interval 1.06-4.16, 26% v. 44%,

conclusionThis study suggests the use of an intraoperative diuretic (furosemide or mannitol) may result in a reduction in DGF in patients undergoing kidney transplantation. Further study in the form of a randomized controlled trial is warranted.

Indexed as

DiureticsKidney TransplantationAdultCohort StudiesDelayed Graft FunctionFurosemideHumansMannitolProspective StudiesRisk FactorsTissue DonorsDiureticsFurosemideMannitol

Identifiers

PMID38575180
PMCPMC11001381
OpenAlexW4393949245

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.