Evidence map›Paper›PMID 38575048›Full record

ArticleBone2024

Effects of dietary iron deficiency or overload on bone: Dietary details matter.

Ulrike Baschant, Brie K Fuqua, Maria Ledesma-Colunga, Christopher D Vulpe, Stela McLachlan, Lorenz C Hofbauer, Aldons J Lusis, Martina Rauner

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bone, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Ulrike BaschantDepartment of Medicine III & Center for Healthy Aging, Technische Universität Dresden, Germany.
Brie K FuquaDepartment of Medicine, Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Maria Ledesma-ColungaDepartment of Medicine III & Center for Healthy Aging, Technische Universität Dresden, Germany.
Christopher D VulpeDepartment of Physiological Sciences, University of Florida Center for Environmental and Human Toxicology, University of Florida, Gainesville, FL 32611, USA.
Stela McLachlanUsher Institute, The University of Edinburgh, Edinburgh, UK.
Lorenz C HofbauerDepartment of Medicine III & Center for Healthy Aging, Technische Universität Dresden, Germany.
Aldons J LusisDepartment of Medicine, Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Martina RaunerDepartment of Medicine III & Center for Healthy Aging, Technische Universität Dresden, Germany. Electronic address: martina.rauner@ukdd.de.
TU Dresden · DEUniversity of California, Los Angeles · USUniversity of Edinburgh · GBUniversity of Florida · US

Funding

Systems genomics of metabolic syndrome traitsP01HL028481 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LUSIS, ALDONS JAKE · 1985 to 2019
$50.2M
Vascular Biology Training GrantT32HL069766 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LUSIS, ALDONS JAKE · 2002 to 2022
$7.4M
An integrated molecular approach to understand variation in iron metabolismR01GM083198 · NIGMS · UNIVERSITY OF FLORIDA · PI VULPE, CHRISTOPHER D · 2012 to 2015
$2.7M
NHLBI NIH HHS P01 HL028481NHLBI NIH HHS T32 HL069766NIGMS NIH HHS R01 GM083198
6 · The paper itself

Abstract

purposeBone is susceptible to fluctuations in iron homeostasis, as both iron deficiency and overload are linked to poor bone strength in humans. In mice, however, inconsistent results have been reported, likely due to different diet setups or genetic backgrounds. Here, we assessed the effect of different high and low iron diets on bone in six inbred mouse strains (C57BL/6J, A/J, BALB/cJ, AKR/J, C3H/HeJ, and DBA/2J).

methodsMice received a high (20,000 ppm) or low-iron diet (∼10 ppm) after weaning for 6-8 weeks. For C57BL/6J males, we used two dietary setups with similar amounts of iron, yet different nutritional compositions that were either richer ("TUD study") or poorer ("UCLA study") in minerals and vitamins. After sacrifice, liver, blood and bone parameters as well as bone turnover markers in the serum were analyzed.

resultsAlmost all mice on the UCLA study high iron diet had a significant decrease of cortical and trabecular bone mass accompanied by high bone resorption. Iron deficiency did not change bone microarchitecture or turnover in C57BL/6J, A/J, and DBA/2J mice, but increased trabecular bone mass in BALB/cJ, C3H/HeJ and AKR/J mice. In contrast to the UCLA study, male C57BL/6J mice in the TUD study did not display any changes in trabecular bone mass or turnover on high or low iron diet. However, cortical bone parameters were also decreased in TUD mice on the high iron diet.

conclusionThus, these data show that cortical bone is more susceptible to iron overload than trabecular bone and highlight the importance of a nutrient-rich diet to potentially mitigate the negative effects of iron overload on bone.

Indexed as

Bone and BonesIron OverloadAnimalsDietIron DeficienciesIron, DietaryLiverMaleMiceMice, Inbred C57BLIron, DietaryBoneiron deficiencyiron dietiron overloadMouse strains

Identifiers

PMID38575048
PMCPMC13456107
OpenAlexW4393533422

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.