Evidence map›Paper›PMID 38574841›Full record

ArticleRegulatory toxicology and pharmacology : RTP2024

Evaluation of in silico model predictions for mammalian acute oral toxicity and regulatory application in pesticide hazard and risk assessment.

Patricia L Bishop, Kamel Mansouri, William P Eckel, Michael B Lowit, David Allen, Amy Blankinship, Anna B Lowit, D Ethan Harwood, Tamara Johnson, Nicole C Kleinstreuer

Abstract read
In one paragraph

Article in Regulatory toxicology and pharmacology : RTP, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Environmental science & technology · 2025
    Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Patricia L BishopAnimal Research Issues, The Humane Society of the United States, Washington, DC, USA. Electronic address: pbishop@humanesociety.org.
Kamel MansouriNational Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
William P EckelUS Environmental Protection Agency, Office of Pesticide Programs, Washington, DC, USA.
Michael B LowitUS Environmental Protection Agency, Office of Pesticide Programs, Washington, DC, USA.
David AllenPredictive Toxicology and Information Sciences Group, Discovery and Safety Assessment Division, Inotiv, Morrisville, NC, USA.
Amy BlankinshipUS Environmental Protection Agency, Office of Pesticide Programs, Washington, DC, USA.
Anna B LowitUS Environmental Protection Agency, Office of Pollution Prevention and Toxics, Washington, DC, USA.
D Ethan HarwoodUS Environmental Protection Agency, Office of Pesticide Programs, Washington, DC, USA.
Tamara JohnsonUS Environmental Protection Agency, Office of Pesticide Programs, Washington, DC, USA.
Nicole C KleinstreuerNational Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.

Funding

Roles of Chromatin-modifying Factors in Epigenetic Control of the GenomeZIABC011208 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI GREWAL, SHIVINDER S · 2009 to 2025
$28.1M
Preclinical drug development in pancreatic cancerZIABC011267 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI RUDLOFF, UDO · 2010 to 2025
$23.9M
Characterization And Functional Significance Of P450 Arachidonate EpoxygenasesZIAES025034 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI ZELDIN, DARRYL C · 2009 to 2025
$18.6M
Scientific Cyberinfrastructure Research ProgramZIAES103385 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI WALKER, VICKIE · 2022 to 2025
$17.4M
Thymus biologyZIABC011806 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI TAKAHAMA, YOUSUKE · 2018 to 2025
$13.5M
Neuroprotective role of GLP-1 receptor agonists (Neurodegenerative disorders & Alzheimer's disease)ZIAAG000333 · NIA · NATIONAL INSTITUTE ON AGING · PI GREIG, NIGEL H. · 2009 to 2025
$10.9M
Structural and Functional Characterization of AllergensZIAES102906 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI MUELLER, GEOFFREY · 2010 to 2025
$10.0M
Consumer Products and Therapeutics Research ProgramZIAES103379 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI TAYLOR, KYLA · 2022 to 2025
$9.9M
Development and translation of novel therapies for pediatric sarcomaZIABC011774 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI HESKE, CHRISTINE · 2017 to 2025
$9.3M
ALZHEIMERS RESEARCH PROJECT: Alzheimer's disease drug developmentZIAAG000469 · NIA · NATIONAL INSTITUTE ON AGING · PI GREIG, NIGEL H. · 2019 to 2025
$6.7M
Research Operations Supporting the National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological MethodsZICES103386 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI HOGBERG-DURDOCK, HELENA · 2022 to 2025
$3.3M
Intramural NIH HHS Z99 ES999999Intramural NIH HHS ZIC ES103386
6 · The paper itself

Abstract

The United States Environmental Protection Agency (USEPA) uses the lethal dose 50% (LD

Indexed as

Computer SimulationPesticidesQuantitative Structure-Activity RelationshipToxicity Tests, AcuteUnited States Environmental Protection AgencyAdministration, OralAnimalsLethal Dose 50RatsReproducibility of ResultsRisk AssessmentUnited StatesPesticidesAcute oral toxicityAlternative approachesHazard assessmentIn silico modelsLD(50)NAMsNon-animal methodsPesticidesRegulatory testingRisk assessment

Identifiers

PMID38574841
PMCPMC11583330

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.