Evidence map›Paper›PMID 38574736›Full record

ArticleCell reports. Medicine2024

Synaptic injury in the inner plexiform layer of the retina is associated with progression in multiple sclerosis.

Christian Cordano, Sebastian Werneburg, Ahmed Abdelhak, Daniel J Bennett, Alexandra Beaudry-Richard, Greg J Duncan, Frederike C Oertel, W John Boscardin, Hao H Yiu, Nora Jabassini and 15 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
9.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
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  4. Inner Plexiform Layer Microstructure Is Altered in Multiple Sclerosis.Investigative ophthalmology & visual science · 2026
    Article
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  8. SV2A PET reveals synaptic density loss in experimental autoimmune encephalomyelitis and in a pilot multiple sclerosis study.Proceedings of the National Academy of Sciences of the United States of America · 2026
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  19. Review
  20. Pharmaceuticals (Basel, Switzerland) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 5 institutions in 2 countries.

Christian CordanoUCSF Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA; Department of Neurology, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy; IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Sebastian WerneburgDepartment of Neurobiology, Brudnik Neuropsychiatric Research Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA; Department of Ophthalmology & Visual Sciences, Michigan Neuroscience Institute, University of Michigan - Michigan Medicine, Ann Arbor, MI, USA.
Ahmed AbdelhakUCSF Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Daniel J BennettUCSF Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Alexandra Beaudry-RichardUCSF Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Greg J DuncanJungers Center for Neurosciences Research, Department of Neurology, Oregon Health & Science University, Portland, OR, USA.
Frederike C OertelUCSF Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
W John BoscardinDepartment of Biostatistics, University of California, San Francisco, San Francisco, CA, USA.
Hao H YiuDepartment of Biology, University of Maryland, College Park, MD, USA.
Nora JabassiniUCSF Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Lauren MerrittDepartment of Neurobiology, Brudnik Neuropsychiatric Research Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Sonia NoceraUCSF Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Jung H SinUCSF Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Isaac P SamanaUCSF Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Shivany Y Condor MontesUCSF Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Kirtana AnanthUCSF Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Antje BischofUCSF Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
UCSF MS EPIC TeamUCSF Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Bardia NourbakhshDepartment of Neurology, Johns Hopkins University, Baltimore, MD, USA.
Stephen L HauserUCSF Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Bruce A C CreeUCSF Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Ben EmeryJungers Center for Neurosciences Research, Department of Neurology, Oregon Health & Science University, Portland, OR, USA.
Dorothy P SchaferDepartment of Neurobiology, Brudnik Neuropsychiatric Research Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Jonah R ChanUCSF Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA. Electronic address: jonah.chan@ucsf.edu.
Ari J GreenUCSF Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA. Electronic address: agreen@ucsf.edu.
University of California, San Francisco · USUniversity of Massachusetts Chan Medical School · USOregon Health & Science University · USJohns Hopkins University · USUniversity of Maryland, College Park · US

Funding

The Role of B cells in the Origin and Progression of Multiple SclerosisR35NS111644 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STEPHEN L HAUSER · 2019 to 2026
$9.1M
How Do Synaptic Connections Change in Demyelinating Disease?R01NS117533 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SCHAFER, DOROTHY PATRICIA · 2021 to 2025
$2.2M
Neuronal responses to chronic demyelinationR01NS120981 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI EMERY, BEN · 2021 to 2025
$2.1M
Establishing VEP as a quantitative biomarker for remyelination using transgenic models for gain and loss of functionR01NS105741 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GREEN, ARI J · 2018 to 2022
$1.8M
Dissecting the impact of senescence on microglia function and neurodegenerationR01AG068281 · NIA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SCHAFER, DOROTHY PATRICIA, ZHANG, HONG · 2024 to 2024
$419k
NIA NIH HHS R01 AG068281NINDS NIH HHS R01 NS105741NINDS NIH HHS R01 NS117533NINDS NIH HHS R01 NS120981NINDS NIH HHS R35 NS111644
6 · The paper itself

Abstract

While neurodegeneration underlies the pathological basis for permanent disability in multiple sclerosis (MS), predictive biomarkers for progression are lacking. Using an animal model of chronic MS, we find that synaptic injury precedes neuronal loss and identify thinning of the inner plexiform layer (IPL) as an early feature of inflammatory demyelination-prior to symptom onset. As neuronal domains are anatomically segregated in the retina and can be monitored longitudinally, we hypothesize that thinning of the IPL could represent a biomarker for progression in MS. Leveraging our dataset with over 800 participants enrolled for more than 12 years, we find that IPL atrophy directly precedes progression and propose that synaptic loss is predictive of functional decline. Using a blood proteome-wide analysis, we demonstrate a strong correlation between demyelination, glial activation, and synapse loss independent of neuroaxonal injury. In summary, monitoring synaptic injury is a biologically relevant approach that reflects a potential driver of progression.

Indexed as

Multiple SclerosisAnimalsAtrophyHumansModels, AnimalNeuronsRetinablood biomarkersdemyelinationEAEexperimental autoimmune encephalomyelitisoptical coherence tomographyretinaserum proteomicssynaptic injury

Identifiers

PMID38574736
PMCPMC11031420
OpenAlexW4393898855

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.