ArticleCurrent biology : CB2024
A receptor required for chitin perception facilitates arbuscular mycorrhizal associations and distinguishes root symbiosis from immunity.
Article in Current biology : CB, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- From invitation to eviction: How plants control arbuscular mycorrhizal symbiosis.Plant signaling & behavior · 2026Review
- The Mitogen-Activated Protein Kinase GhNTF3 Modulates the Arbuscular Mycorrhizal Symbiosis-Immunity Trade-Off in Cotton by Regulating Salicylic Acid Biosynthesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- CNGCs in Marchantia paleacea uncouple arbuscular mycorrhizal symbiosis and rhizoid development.The New phytologist · 2026Article
- Paralogous LRR receptor kinases confer symbiosis specificity between arbuscular mycorrhizal and root nodule symbioses in Lotus japonicus.The New phytologist · 2026Article
- An NSP2-MYB module orchestrates flavonoid biosynthesis and nodule symbiosis.Current biology : CB · 2026Article
- Enrichment is not necessarily recruitment in root microbiome assembly.The ISME journal · 2026Review
- Molecular mechanisms modulating beneficial plant root-microbe interactions: What's common?Plant communications · 2026Review
- Microbial chitinases in the plant holobiont: ecological roles and structural determinants.FEMS microbiology reviews · 2026Review
- A GmNRF5a-GmCERK1-GmCAK1 module mediates chitin/chitosan-triggered immune response in soybean.Journal of integrative plant biology · 2026Article
- Beyond phosphate uptake: PT4/PT11 as key functional components linking phosphate acquisition, nutrient exchange, and arbuscule maintenance in arbuscular mycorrhizal symbiosis.Frontiers in plant science · 2026Review
- Article
- The receptor-like cytoplasmic kinase AeRLCK2 mediates Nod-independent rhizobial symbiosis in Aeschynomene legumes.The Plant cell · 2025Article
- Several groups of LysM-RLKs are involved in symbiotic signal perception and arbuscular mycorrhiza establishment.Nature communications · 2025Article
- A plant Lysin Motif Receptor-Like Kinase plays an ancestral function in mycorrhiza.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Enacting partner specificity in legume-rhizobia symbioses.aBIOTECH · 2025Review
- The Medicago truncatula LYR4 intracellular domain serves as a scaffold in immunity signaling independent of its phosphorylation activity.The New phytologist · 2025Article
- Ethylene promotes SMAX1 accumulation to inhibit arbuscular mycorrhiza symbiosis.Nature communications · 2025Article
- Review
- Evolution of small molecule-mediated regulation of arbuscular mycorrhiza symbiosis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- A gap in the recognition of two mycorrhizal factors: new insights into two LysM-type mycorrhizal receptors.Frontiers in plant science · 2024Review
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plants establish symbiotic associations with arbuscular mycorrhizal fungi (AMF) to facilitate nutrient uptake, particularly in nutrient-limited conditions. This partnership is rooted in the plant's ability to recognize fungal signaling molecules, such as chitooligosaccharides (chitin) and lipo-chitooligosaccharides. In the legume Medicago truncatula, chitooligosaccharides trigger both symbiotic and immune responses via the same lysin-motif-receptor-like kinases (LysM-RLKs), notably CERK1 and LYR4. The nature of plant-fungal engagement is opposite according to the outcomes of immunity or symbiosis signaling, and as such, discrimination is necessary, which is challenged by the dual roles of CERK1/LYR4 in both processes. Here, we describe a LysM-RLK, LYK8, that is functionally redundant with CERK1 for mycorrhizal colonization but is not involved in chitooligosaccharides-induced immunity. Genetic mutation of both LYK8 and CERK1 blocks chitooligosaccharides-triggered symbiosis signaling, as well as mycorrhizal colonization, but shows no further impact on immunity signaling triggered by chitooligosaccharides, compared with the mutation of CERK1 alone. LYK8 interacts with CERK1 and forms a receptor complex that appears essential for chitooligosaccharides activation of symbiosis signaling, with the lyk8/cerk1 double mutant recapitulating the impact of mutations in the symbiosis signaling pathway. We conclude that this novel receptor complex allows chitooligosaccharides activation specifically of symbiosis signaling and helps the plant to differentiate between activation of these opposing signaling processes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.