Evidence map›Paper›PMID 38574456›Full record

ArticleBiomaterials2024

Vaso-Lock for sutureless anastomosis in a pig arteriovenous loop model.

Xiaowei Li, Emma R Young, Cameron Martin, Joseph G Ribaudo, Mohamed Zaghloul, Sophia Roberts, Rodrigo Meade, Batool Arif, William R Moritz, Sarah Madira and 6 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Xiaowei LiDivision of Plastic and Reconstructive Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, MO, 63110, USA. Electronic address: xiaoweili@wustl.edu.
Emma R YoungDivision of Plastic and Reconstructive Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Cameron MartinDivision of Plastic and Reconstructive Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Joseph G RibaudoDivision of Plastic and Reconstructive Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Mohamed ZaghloulSection of Vascular Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Sophia RobertsSection of Vascular Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Rodrigo MeadeSection of Vascular Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Batool ArifSection of Vascular Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, MO, 63110, USA.
William R MoritzDivision of Plastic and Reconstructive Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Sarah MadiraDivision of Plastic and Reconstructive Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Jonathon B SchofieldDivision of Plastic and Reconstructive Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Helen XunDepartment of Plastic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
Caitlin W HicksDivision of Vascular Surgery and Endovascular Therapy, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
Sung H KangDepartment of Mechanical Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA.
Mohamed A ZayedSection of Vascular Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, MO, 63110, USA; Division of Molecular Cell Biology, Washington University School of Medicine, St. Louis, MO, 63110, USA; Department of Biomedical Engineering, McKelvey School of Engineering, Washington University in St. Louis, MO, 63130, USA; St. Louis Veterans Affairs Health Care System, St. Louis, MO, 63106, USA. Electronic address: zayedm@wustl.edu.
Justin M SacksDivision of Plastic and Reconstructive Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, MO, 63110, USA. Electronic address: jmsacks@wustl.edu.
Washington University in St. Louis · USJohns Hopkins University · US

Funding

WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Neuroscience Training Program at Washington UniversityT32NS121881 · NINDS · WASHINGTON UNIVERSITY · PI Martha W Bagnall, Daniel Kerschensteiner · 2021 to 2026
$3.1M
CCR2 Targeted Molecular Imaging and Treatment of Abdominal Aortic AneurysmsR01HL153436 · NHLBI · WASHINGTON UNIVERSITY · PI GROPLER, ROBERT J., ZAYED, MOHAMED A. · 2020 to 2023
$3.0M
Regulation of Endothelial Lipid Metabolism in the Setting of Diabetes and Critical Limb Ischemia to Prevent Surgical ComplicationsR01HL153262 · NHLBI · WASHINGTON UNIVERSITY · PI ZAYED, MOHAMED A. · 2021 to 2024
$2.1M
Bioengineered Composite for the Treatment of Peripheral Arterial DiseaseR01HL168513 · NHLBI · WASHINGTON UNIVERSITY · PI Xiaowei Li · 2023 to 2026
$2.0M
Multi-Modal Venus Clot Removal DeviceR41HL150963 · NHLBI · CAELI VASCULAR, LLC · PI ZAYED, MOHAMED A. · 2020 to 2020
$194k
NCATS NIH HHS UL1 TR002345NHLBI NIH HHS R01 HL153262NHLBI NIH HHS R01 HL153436NHLBI NIH HHS R01 HL168513NHLBI NIH HHS R41 HL150963NINDS NIH HHS T32 NS121881
6 · The paper itself

Abstract

A vascular anastomosis is a critical surgical skill that involves connecting blood vessels. Traditional handsewn techniques can be challenging and resource intensive. To address these issues, we have developed a unique sutureless anastomotic device called Vaso-Lock. This intraluminal device connects free vascular ends using anchors to maintain traction and enable a rapid anastomosis. We tested the anastomotic capability of Vaso-Locks in a pig common carotid-internal jugular arteriovenous model. The use of Vaso-Lock allowed us to accomplish this procedure in less than 10 min, in contrast to the approximately 40 min required for a handsewn anastomosis. The Vaso-Lock effectively maintained patency for at least 6 weeks without causing significant tissue damage. Histological analysis revealed that the device was successfully incorporated into the arterial wall, promoting a natural healing process. Additionally, organ evaluations indicated no adverse effects from using the Vaso-Lock. Our findings support the safety and effectiveness of the Vaso-Lock for arteriovenous anastomosis in pigs, with potential applicability for translation to humans. Our novel sutureless device has the potential to advance surgical practice and improve patient outcomes.

Indexed as

Anastomosis, SurgicalAnimalsArteriovenous AnastomosisSutureless Surgical ProceduresSwineVascular PatencyArteriovenousSuturelessVascular anastomosisVaso-Lock device

Identifiers

PMID38574456
PMCPMC11453428
OpenAlexW4393385019

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.