Evidence map›Paper›PMID 38574279›Full record

ArticleAmerican journal of respiratory cell and molecular biology2024

IL-10 Counteracts IFN-γ to Alleviate Acute Lung Injury in a Viral-Bacterial Superinfection Model.

Michael McKelvey, Md Bashir Uddin, Sunil Palani, Shengjun Shao, Keer Sun

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 15 citations in OpenAlex.

  1. Liquid Lung Rest During Extracorporeal Life Support in a Neonatal Porcine Model of Acute Lung Injury.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2026
    Article
  2. Article
  3. Distinct Blood and Lung Proteins Drive Pulmonary Capillary Leak in Children With Severe Hypoxemic Respiratory Failure.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2026
    Observational
  4. Article
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  6. Article
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  8. Review
  9. Article
  10. Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2025
    Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. A Tale of Two Cytokines: IL-10 Blocks IFN-γ in Influenza A Virus-American journal of respiratory cell and molecular biology · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Michael McKelveyDepartment of Pathology and.
Md Bashir UddinDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas.ORCID 0000-0002-0045-9669
Sunil PalaniDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas.
Shengjun ShaoDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas.
Keer SunDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas.ORCID 0000-0002-9702-9584
The University of Texas Medical Branch at Galveston · US

Funding

Oxidative Burst in Influenza and MRSA Co-infectionR01HL118408 · NHLBI · UNIVERSITY OF TEXAS MED BR GALVESTON · PI SUN, KEER · 2013 to 2022
$3.9M
NHLBI NIH HHS R01 HL118408NIH HHS R01 HL118408
6 · The paper itself

Abstract

Immune activation is essential for lung control of viral and bacterial infection, but an overwhelming inflammatory response often leads to the onset of acute respiratory distress syndrome. IL-10 plays a crucial role in regulating the balance between antimicrobial immunity and immunopathology. In the present study, we investigated the role of IL-10 in acute lung injury induced by influenza A virus and methicillin-resistant

Indexed as

Acute Lung InjuryDisease Models, AnimalInterferon-gammaInterleukin-10SuperinfectionAnimalsCoinfectionInfluenza A virusLungMethicillin-Resistant Staphylococcus aureusMiceMice, Inbred C57BLMice, KnockoutOrthomyxoviridae InfectionsStaphylococcal InfectionsIL10 protein, mouseInterferon-gammaInterleukin-10acute lung injuryIL-10influenzapneumoniaS. aureus

Identifiers

PMID38574279
PMCPMC11225870
OpenAlexW4393928222

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.