Evidence map›Paper›PMID 38573855›Full record

ArticleCell reports2024

Tactile processing in mouse cortex depends on action context.

Eric A Finkel, Yi-Ting Chang, Rajan Dasgupta, Emily E Lubin, Duo Xu, Genki Minamisawa, Anna J Chang, Jeremiah Y Cohen, Daniel H O'Connor

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Perceptual choice and motor signals in mouse somatosensory cortex.bioRxiv : the preprint server for biology · 2024
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Eric A FinkelSolomon H. Snyder Department of Neuroscience, Krieger Mind/Brain Institute, Kavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, MD 21218, USA.
Yi-Ting ChangSolomon H. Snyder Department of Neuroscience, Krieger Mind/Brain Institute, Kavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, MD 21218, USA.
Rajan DasguptaSolomon H. Snyder Department of Neuroscience, Krieger Mind/Brain Institute, Kavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, MD 21218, USA.
Emily E LubinSolomon H. Snyder Department of Neuroscience, Krieger Mind/Brain Institute, Kavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, MD 21218, USA.
Duo XuSolomon H. Snyder Department of Neuroscience, Krieger Mind/Brain Institute, Kavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, MD 21218, USA.
Genki MinamisawaSolomon H. Snyder Department of Neuroscience, Krieger Mind/Brain Institute, Kavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, MD 21218, USA.
Anna J ChangSolomon H. Snyder Department of Neuroscience, Krieger Mind/Brain Institute, Kavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, MD 21218, USA.
Jeremiah Y CohenSolomon H. Snyder Department of Neuroscience, Krieger Mind/Brain Institute, Kavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, MD 21218, USA.
Daniel H O'ConnorSolomon H. Snyder Department of Neuroscience, Krieger Mind/Brain Institute, Kavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, MD 21218, USA. Electronic address: dan.oconnor@jhmi.edu.
Johns Hopkins University · USDiscovery Institute · US

Funding

Murine Mutagenesis CoreP30NS050274 · NINDS · JOHNS HOPKINS UNIVERSITY · PI KOLODKIN, ALEX L · 2005 to 2020
$10.9M
Norepinephrine modulation of neocortex during flexible behaviorR01NS104834 · NINDS · JOHNS HOPKINS UNIVERSITY · PI COHEN, JEREMIAH YAACOV, O'CONNOR, DANIEL HANS · 2018 to 2022
$4.1M
Circuit and cellular dynamics in mouse cortex during tactile detectionR01NS089652 · NINDS · JOHNS HOPKINS UNIVERSITY · PI O'CONNOR, DANIEL HANS · 2014 to 2019
$2.1M
NINDS NIH HHS P30 NS050274NINDS NIH HHS R01 NS089652NINDS NIH HHS R01 NS104834
6 · The paper itself

Abstract

The brain receives constant tactile input, but only a subset guides ongoing behavior. Actions associated with tactile stimuli thus endow them with behavioral relevance. It remains unclear how the relevance of tactile stimuli affects processing in the somatosensory (S1) cortex. We developed a cross-modal selection task in which head-fixed mice switched between responding to tactile stimuli in the presence of visual distractors or to visual stimuli in the presence of tactile distractors using licking movements to the left or right side in different blocks of trials. S1 spiking encoded tactile stimuli, licking actions, and direction of licking in response to tactile but not visual stimuli. Bidirectional optogenetic manipulations showed that sensory-motor activity in S1 guided behavior when touch but not vision was relevant. Our results show that S1 activity and its impact on behavior depend on the actions associated with a tactile stimulus.

Indexed as

Somatosensory CortexAnimalsBehavior, AnimalFemaleMaleMiceMice, Inbred C57BLOptogeneticsTouchTouch Perceptionbehavioral contextCP: NeuroscienceS1sensorimotorsensory processingsomatosensory cortex

Identifiers

PMID38573855
PMCPMC11097894
OpenAlexW4393870203

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.