ArticleeLife2024
Context-dependent modification of PFKFB3 in hematopoietic stem cells promotes anaerobic glycolysis and ensures stress hematopoiesis.
Erratum issuedOpen access · goldAbstract read
In one paragraph
Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers.
0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 7 citations in OpenAlex.
- Hematopoietic Stem Cell Metabolism during Stress and Aging.Advances in geriatric medicine and research · 2026Article
- The impact of lactate and lipid metabolism in microglia upon cognitive impairment following radiation-induced brain injury.Journal of translational medicine · 2026Review
- Stem cell functionbioRxiv : the preprint server for biology · 2026Article
- Intrinsic and niche-dependent metabolic regulation of haematopoietic stem cells and implications for leukaemogenesis.Nature cell biology · 2026Review
- Glucose Metabolic Enzyme PFKFB3 in Cardiopulmonary Vascular Health and Disease.Circulation research · 2026Review
- The Mechanosensation-Metabolism-Inflammation Axis: The Central Role of Piezo1 and TRPV4 in Hypertension-Related Atherosclerosis.International journal of general medicine · 2026Review
- Metabolism and HSC fate: what NADPH is made for.Trends in cell biology · 2025Review
- Article
- Advances in the understanding of the role and mechanism of action of PFKFB3‑mediated glycolysis in liver fibrosis (Review).International journal of molecular medicine · 2024Review
- Targeting the PRMT1-cGAS-STING signaling pathway to enhance the anti-tumor therapeutic efficacy.Journal of cancer biology · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
28 authors at 13 institutions in 4 countries.
Shintaro Watanuki *Department of Stem Cell Biology, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.ORCID https://orcid.org/0000-0002-9229-6712
Hiroshi Kobayashi *Department of Stem Cell Biology, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.ORCID https://orcid.org/0000-0002-0924-1252
Yuki SugiuraDepartment of Biochemistry, Keio University School of Medicine, Tokyo, Japan.ORCID https://orcid.org/0000-0002-6983-8958
Masamichi YamamotoDepartment of Research Promotion and Management, National Cerebral and Cardiovascular Center, Osaka, Japan.
Daiki KariganeDepartment of Stem Cell Biology, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.ORCID https://orcid.org/0000-0002-4017-5193
Kohei ShiroshitaDepartment of Stem Cell Biology, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
Yuriko SorimachiDepartment of Stem Cell Biology, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
Shinya FujitaDepartment of Stem Cell Biology, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
Takayuki MorikawaDepartment of Stem Cell Biology, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
Shuhei KoideDivision of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, University of Tokyo, Tokyo, Japan.
Motohiko OshimaDivision of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, University of Tokyo, Tokyo, Japan.
Akira NishiyamaDepartment of Immunology, Yokohama City University Graduate School of Medicine, Kanagawa, Japan.
Koichi MurakamiDepartment of Immunology, Yokohama City University Graduate School of Medicine, Kanagawa, Japan.
Miho HaraguchiDepartment of Stem Cell Biology, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
Shinpei TamakiDepartment of Stem Cell Biology, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
Takehiro YamamotoDepartment of Biochemistry, Keio University School of Medicine, Tokyo, Japan.ORCID https://orcid.org/0000-0003-4974-9859
Tomohiro YabushitaDivision of Cellular Therapy, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Yosuke TanakaInternational Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan.
Go NagamatsuCenter for Advanced Assisted Reproductive Technologies, University of Yamanashi, Yamanashi, Japan.
Hiroaki HondaField of Human Disease Models, Major in Advanced Life Sciences and Medicine, Institute of Laboratory Animals, Tokyo Women's Medical University, Tokyo, Japan.
Shinichiro OkamotoDivision of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Nobuhito GodaDepartment of Life Sciences and Medical BioScience, Waseda University School of Advanced Science and Engineering, Tokyo, Japan.
Tomohiko TamuraDepartment of Immunology, Yokohama City University Graduate School of Medicine, Kanagawa, Japan.
Ayako Nakamura-IshizuDepartment of Microscopic and Developmental Anatomy, Tokyo Women's Medical University, Tokyo, Japan.
Makoto SuematsuDepartment of Biochemistry, Keio University School of Medicine, Tokyo, Japan.
Atsushi IwamaDivision of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, University of Tokyo, Tokyo, Japan.ORCID https://orcid.org/0000-0001-9410-8992
Toshio SudaInternational Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan.
Keiyo TakuboDepartment of Stem Cell Biology, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.ORCID https://orcid.org/0000-0002-1736-7592
Keio University · JPInstitute for Stem Cell Biology and Regenerative Medicine · INNational Center for Global Health and Medicine · JPTohoku University · JPTokyo Women's Medical University · JPWaseda University · JPYokohama City University Medical Center · JPJapan Science and Technology Agency · JPKumamoto University · JPNational Cerebral and Cardiovascular Center · JPNational University of Singapore · SGThe University of Tokyo · JPYokohama City University · JP
Funding
Japan Agency for Medical Research and Development JP18ae0201014Japan Agency for Medical Research and Development JP18ck0106444Japan Agency for Medical Research and Development JP20bm0704042Japan Agency for Medical Research and Development JP20gm1210011Japan Agency for Medical Research and Development JP22zf0127007MEXT/JSPS JP18H02845MEXT/JSPS JP19K17847MEXT/JSPS JP19K17877MEXT/JSPS JP20K21621MEXT/JSPS JP21H02957MEXT/JSPS JP21J01690MEXT/JSPS JP21K08431MEXT/JSPS JP22K08493MEXT/JSPS JP 22K19550Ministry of Education, Culture, Sports, Science and Technology Human Biology Microbiome Quantum Research Center (WPI-Bio2Q)Ministry of Education, Culture, Sports, Science and Technology MEXT Joint Usage/Research Center Program at the Advanced Medical Research Center Yokohama City UnivNational Center for Global Health and Medicine 20A1010National Center for Global Health and Medicine 21A2001National Center for Global Health and Medicine 23A1004National Center for Global Health and Medicine 23A2002National Center for Global Health and Medicine 26-001National Center for Global Health and Medicine 29-1015
Abstract
Metabolic pathways are plastic and rapidly change in response to stress or perturbation. Current metabolic profiling techniques require lysis of many cells, complicating the tracking of metabolic changes over time after stress in rare cells such as hematopoietic stem cells (HSCs). Here, we aimed to identify the key metabolic enzymes that define differences in glycolytic metabolism between steady-state and stress conditions in murine HSCs and elucidate their regulatory mechanisms. Through quantitative
Indexed as
GlycolysisPhosphofructokinase-2Adenosine TriphosphateAnaerobiosisAnimalsHematopoiesisHematopoietic Stem CellsMiceOxidative PhosphorylationPhosphoric Monoester HydrolasesAdenosine TriphosphatePFKFB3 protein, mousePhosphofructokinase-2Phosphoric Monoester Hydrolaseshematioietic stem cellmetabolomicsmousePFKFB3regenerative medicinesingle-cell atp analysisstem cell metabolismstem cellsstress hematopoiesis
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.