Evidence map›Paper›PMID 38573466›Full record

ArticleDiabetes therapy : research, treatment and education of diabetes and related disorders2024

An Obesity-Centric Approach with and Without Anti-Obesity Medications Compared to the Usual-Care Approach to Management of Patients with Obesity and Type 2 Diabetes in an Employer Setting: A Pragmatic Randomized Controlled Trial (EMPOWER-T2D).

Kevin M Pantalone, Bruce Rogen, Patty Zirm, Huijun Xiao, James Bena, Gretchen Barnard, Elena Borukh, Seenia Peechakara, Marcio L Griebeler, James B Young and 1 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetes therapy : research, treatment and education of diabetes and related disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03799198 (Real World Effectiveness of Combining an Employer-based Weight Management Program With Medication for Chronic Weight Management in Employees With Obesity - a Pragmatic Randomized Trial), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03799198 phase4completednot on this map

Real World Effectiveness of Combining an Employer-based Weight Management Program With Medication for Chronic Weight Management in Employees With Obesity - a Pragmatic Randomized Trial

TypeinterventionalSponsorNovo Nordisk A/SRan2019 to 2020Enrolled200ConditionsObesityArmsWeight Management Program (WMP), Medication for chronic weight management (Rx)
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Kevin M PantaloneDepartment of Endocrinology, Diabetes, and Metabolism, Cleveland Clinic, Cleveland, OH, USA.
Bruce RogenEmployee Health Plan, Cleveland Clinic, Cleveland, OH, USA.
Patty ZirmEmployee Health Plan, Cleveland Clinic, Cleveland, OH, USA.
Huijun XiaoDepartment of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA.
James BenaDepartment of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA.
Gretchen BarnardDepartment of Endocrinology, Diabetes, and Metabolism, Cleveland Clinic, Cleveland, OH, USA.
Elena BorukhDepartment of Endocrinology, Diabetes, and Metabolism, Cleveland Clinic, Cleveland, OH, USA.
Seenia PeechakaraDepartment of Endocrinology, Diabetes, and Metabolism, Cleveland Clinic, Cleveland, OH, USA.
Marcio L GriebelerDepartment of Endocrinology, Diabetes, and Metabolism, Cleveland Clinic, Cleveland, OH, USA.
James B YoungCleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland Clinic, Cleveland, OH, USA.
Bartolome BurgueraDepartment of Endocrinology, Diabetes, and Metabolism, Cleveland Clinic, Cleveland, OH, USA. burgueb@ccf.org.ORCID http://orcid.org/0000-0001-9808-8327
Cleveland Clinic · USCleveland Clinic Lerner College of Medicine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThis study aimed to compare weight loss and glycated hemoglobin (HbA

methodsSingle-center, randomized, open-label, 3-armed, parallel-group, pragmatic, noninferiority trial, July 2020 to August 2022. Adults enrolled in the Cleveland Clinic Employee Health Plan (body mass index [BMI] ≥ 30 kg/m

resultsDue to enrollment and retention challenges, largely related to COVID-19, only 74/300 planned participants were randomized and the study was terminated early. Participants were predominantly female (59%), median (interquartile range [IQR]) age 53.5 (47, 60) years, 68% white, with baseline median (IQR) BMI and HbA

conclusionsIncluding anti-obesity medication was associated with superior weight loss with noninferior HbA

trial registrationClinicalTrials.gov NCT03799198.

Indexed as

Body mass indexGlycated hemoglobinObesity treatmentType 2 diabetesWeight changeWeight management

Identifiers

PMID38573466
PMCPMC11043250
OpenAlexW4393932365

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.