ArticleJournal of natural medicines2024
Cryptobuchanosides A-G: seven previously undescribed triterpene glycosides from Cryptolepis buchananii R.Br. ex Roem. and Schult. with nitric oxide production inhibition activity.
Article in Journal of natural medicines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 1 citations in OpenAlex.
- Dracafoliasides A-D, four undescribed spirostanol glycosides from Dracaena angustifolia with nitric oxide production inhibitory activity.Journal of natural medicines · 2026Article
- Discovery of four new malabaricane saponins, malabarosides A-D, from the aerial parts of Dysphania ambrosioides with nitric oxide production inhibitory activity.Journal of natural medicines · 2026Article
- Saponins from cactus and their inhibitory effects on amyloid β aggregation.Journal of natural medicines · 2026Article
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Authors and funding
10 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
In this study, nine triterpene glycosides including seven previously undescribed compounds (1-7), were isolated from leaves of Cryptolepis buchananii R.Br. ex Roem. and Schult. using various chromatographic methods. The chemical structures of the compounds were elucidated to be 3-O-β-D-glucopyranosyl-(1 → 6)-β-D-glucopyranosyluncargenin C 28-O-α-L-rhamnopyranosyl-(1 → 2)-β-D-glucopyranosyl ester (1), 3-O-β-D-glucopyranosyl-(1 → 2)-β-D-glucopyranosyluncargenin C 28-O-α-L-rhamnopyranosyl-(1 → 2)-β-D-glucopyranosyl ester (2), 3-O-β-D-glucopyranosyl-(1 → 2)-β-D-glucopyranosyluncargenin C 28-O-β-D-glucopyranosyl-(1 → 4)-α-L-rhamnopyranosyl-(1 → 2)-β-D-glucopyranosyl ester (3), 3-O-β-D-glucopyranosyl-(1 → 2)-β-D-glucopyranosylhederagenin 28-O-α-L-rhamnopyranosyl-(1 → 2)-β-D-glucopyranosyl ester (4), 3-O-β-D-glucopyranosylarjunolic acid 28-O-α-L-rhamnopyranosyl-(1 → 2)-β-D-glucopyranosyl ester (5), 3-O-β-D-glucopyranosyl-(1 → 2)-β- D-glucopyranosyl-6β,23-dihydroxyursolic acid 28-O-α-L-rhamnopyranosyl-(1 → 2)-β-D-glucopyranosyl ester (6), 3-O-β-D-glucopyranosyl-6β,23-dihydroxyursolic acid 28-O-α-L-rhamnopyranosyl-(1 → 2)-β-D-glucopyranosyl ester (7), asiatic acid 28-O-α-L-rhamnopyranosyl-(1 → 2)-β-D-glucopyranosyl ester (8), and 3-O-β-D-glucopyranosylasiatic acid 28-O-α-L-rhamnopyranosyl-(1 → 2)-β-D-glucopyranosyl ester (9), through infrared, high-resolution electrospray ionization mass spectrometry, one- and two-dimensional nuclear magnetic resonance spectral analyses. The isolates inhibited nitric oxide production in lipopolysaccharide-activated RAW 264.7 cells, with half-maximal inhibitory concentration (IC
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