Evidence map›Paper›PMID 38573401›Full record

ArticleDiscover oncology2024

Fibrin glue mediated direct delivery of radiation sensitizers results in enhanced efficacy of radiation treatment.

Jane Nguyen, Akhil Chandekar, Sophia Laurel, Jazleen Dosanjh, Keya Gupta, Justin Le, Henry Hirschberg

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Discover oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jane Nguyen *Beckman Laser Institute, University of California, Irvine, CA, 92617, USA. janebn1@uci.edu.
Akhil Chandekar *Beckman Laser Institute, University of California, Irvine, CA, 92617, USA.
Sophia LaurelBeckman Laser Institute, University of California, Irvine, CA, 92617, USA.
Jazleen DosanjhBeckman Laser Institute, University of California, Irvine, CA, 92617, USA.
Keya GuptaBeckman Laser Institute, University of California, Irvine, CA, 92617, USA.
Justin LeBeckman Laser Institute, University of California, Irvine, CA, 92617, USA.
Henry HirschbergBeckman Laser Institute, University of California, Irvine, CA, 92617, USA.
University of California, Irvine · USBeckman Laser Institute and Medical Clinic · US

Funding

Norwegian Radium Hospital Research Foundation Grants SE 1305 and SE 1503
6 · The paper itself

Abstract

purposeRadiation therapy (RT) plays an important role in the treatment of glioblastoma multiforme (GBM). However, inherent intrinsic resistance of tumors to radiation, coupled with the need to consider the tolerance of normal tissues and the potential effects on neurocognitive function, impose constraints on the amount of RT that can be safely delivered. A strategy for augmenting the effectiveness of RT involves the utilization of radiation sensitizers (RS). Directly implanting RS-loaded fibrin glue (FG) into the tumor resection cavity would by-pass the blood brain barrier, potentially enhancing the impact of RT on tumor recurrence. This study investigated the ability of FG to incorporate and release, in non-degraded form, the radiation sensitizers 5-Fluorouracil (5FU) and Motexafin gadolinium (MGd).

methodsFG layers were created in a 24-well plate by combining thrombin, fibrinogen, and 5FU or MGd. Supernatants from these layers were collected at various intervals and added to F98 glioma spheroid cultures in 96-well plates. Radiation was applied either before or after RS application as single or fractionated dosages. Spheroid growth was monitored for 14 days.

resultsCombined treatment of FG-released 5FU and RT significantly inhibited spheroid growth compared to RS or RT as a single treatment. As a free drug, MGd demonstrated its efficacy in reducing spheroid volume, but had diminished potency as a released RS. Fractionated radiation was more effective than single dose radiation.

conclusionNon-degraded RS was released from the FG for up to 72 h. FG-released 5FU greatly increased the efficacy of radiation therapy.

Indexed as

Direct delivery systemFibrin glueHydrogelsRadiation sensitizerRadiation therapy

Identifiers

PMID38573401
PMCPMC10994896
OpenAlexW4393942541

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.